The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients
Fahmy, A., Azab, M., E. Amr, G., Helmy, H., Sediq, A. (2023). The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients. EKB Journal Management System, 29(5), 1294-1298. doi: 10.21608/zumj.2022.167791.2659
Alaa Fahmy; Mervat M. Azab; Ghada E. Amr; heba Helmy; Amany Sediq. "The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients". EKB Journal Management System, 29, 5, 2023, 1294-1298. doi: 10.21608/zumj.2022.167791.2659
Fahmy, A., Azab, M., E. Amr, G., Helmy, H., Sediq, A. (2023). 'The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients', EKB Journal Management System, 29(5), pp. 1294-1298. doi: 10.21608/zumj.2022.167791.2659
Fahmy, A., Azab, M., E. Amr, G., Helmy, H., Sediq, A. The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients. EKB Journal Management System, 2023; 29(5): 1294-1298. doi: 10.21608/zumj.2022.167791.2659

The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients

Zagazig University Medical Journal
Article 10, Volume 29, Issue 5, September and October 2023, Page 1294-1298  XML PDF (342.95 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.167791.2659
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Authors
Alaa Fahmy email orcid 1; Mervat M. Azaborcid 2; Ghada E. Amrorcid 3; heba Helmyorcid 4; Amany Sediqorcid 5
1Ministry of Health, Egypt.
2Department of clinical pathology, Faculty of Medicine, Zagazig University, Egypt.
3Department of Clinical Pathology, Faculty of Medicine – Zagazig University, Egypt
4Associate Professor of Anesthesiology and surgical intensive care, Faculty of Medicine, Zagazig University, Egypt
5Department of clinical pathology, Faculty of Medicine, Zagazig University, Egypt
Abstract
Introduction:
As a major health problem, mortality due to sepsis accounts for about 42% in intensive care deaths. This high mortality rate necessitates rapid and accurate diagnosis of sepsis, differentiating it from other confusing conditions. Rapid and evidence-based management is expected to follow. The use of biomarkers gained high attention in the scientific community for sepsis diagnosis. In the current study, we aim to evaluate the diagnostic accuracy of measuring CRP, PCT and MR-proADM in differentiation between septic and non-septic patients within intensive care unit.
Methods:
A total of 64 subjects were enrolled. They were divided into: (1) control group: 32 Non-septic ICU patients, and (2) case group: 32 septic ICU patients. CBC, CRP, PCT, MR-proADM quantification was done at day 1 of sepsis suspension for case group and randomly for control group.
Results:
At a cut-off 78.479 pg/ml, MR-proADM has 93.8 % sensitivity, 90.6 % specificity, 90.9 % positive predictive value, 93.5% negative predictive value and 92.18 % accuracy.
Conclusion:
Based upon our findings, MR-proADM could be useful as a diagnostic marker in sepsis patients admitted to ICU. It had diagnostic criteria comparable to that of PCT and better than that of CRP.
Key words:
Sepsis, ICU, MR-proADM, CRP, PCT
Keywords
Sepsis; ICU; MR-proADM; CRP; PCT
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