Exhaled Carbon Monoxide as a Marker of Inflammation in Hospitalized COVID-19 Patients | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 31, Volume 89, Issue 2, October 2022, Page 6247-6255 PDF (875.75 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2022.268957 | ||||
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Authors | ||||
Walid Elgendy; Saad R. Samra; Ahmed M. Tawfik; Huda Elsayed Mahmoud Said; Ahmed Mohamed Said | ||||
Abstract | ||||
Background: Coronavirus disease 2019 (COVID-19) is a virus that is quickly spreading and has heterogeneous clinical features. Early identification of prognostic variables is necessary to coordinate treatment plans and accurately determine patient severity. Objectives:The aim of the current work was to evaluate the possible value of exhaled carbon monoxide (CO) as a marker of inflammation in different severity categories of hospitalized COVID-19 patients. Patients and Methods: A prospective cohort study was conducted on 39 confirmed COVID-19 nonsmoker patients who admitted to isolation unit at Zagazig University isolation hospital from March 2021 to February 2022. They were divided into two groups: Moderate COVID- 19 and severe COVID- 19. Exhaled carbon monoxide (eCO) was measured on admission (day 1) and after seven days (day 7). Results: It was revealed that there washigh statistically significant difference between the studied groups regarding eCO at day one and seven (the level was significantly higher among severe group) (p≤0.001). Also,there were high significant positive correlations between eCO and CRP level in both moderate and severe groups through day one and seven (p≤0.001). Conclusion: It could be concluded that exhaled CO analysis can be viewed as a noninvasive inflammatory marker for determining the level and severity of inflammation as well as forecasting the prognosis of COVID-19 patients. | ||||
Keywords | ||||
COVID-19; C- reactive protein; Exhaled carbon monoxide | ||||
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