Acute Kidney Injury in Hospitalized Patients with COVID-19; evolution and mortality
Mahmoud, M., El-Deeb, S., El Dahrawy, A., Allam, H. (2023). Acute Kidney Injury in Hospitalized Patients with COVID-19; evolution and mortality. EKB Journal Management System, 29(5), 1299-1310. doi: 10.21608/zumj.2022.173003.2680
Medhat Ibrahim Mahmoud; Salem Ali El-Deeb; Alaa Mohamed El Dahrawy; Hala Mohammed Allam. "Acute Kidney Injury in Hospitalized Patients with COVID-19; evolution and mortality". EKB Journal Management System, 29, 5, 2023, 1299-1310. doi: 10.21608/zumj.2022.173003.2680
Mahmoud, M., El-Deeb, S., El Dahrawy, A., Allam, H. (2023). 'Acute Kidney Injury in Hospitalized Patients with COVID-19; evolution and mortality', EKB Journal Management System, 29(5), pp. 1299-1310. doi: 10.21608/zumj.2022.173003.2680
Mahmoud, M., El-Deeb, S., El Dahrawy, A., Allam, H. Acute Kidney Injury in Hospitalized Patients with COVID-19; evolution and mortality. EKB Journal Management System, 2023; 29(5): 1299-1310. doi: 10.21608/zumj.2022.173003.2680

Acute Kidney Injury in Hospitalized Patients with COVID-19; evolution and mortality

Zagazig University Medical Journal
Article 11, Volume 29, Issue 5, September and October 2023, Page 1299-1310  XML PDF (572.7 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.173003.2680
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Authors
Medhat Ibrahim Mahmoud1; Salem Ali El-Deeb2; Alaa Mohamed El Dahrawy email 3; Hala Mohammed Allam4
1Internal Medicine, Faculty of medicine, zagazig University
2Nephrology department, faculty of medicine, Zagazig university, Zagazig, Egypt
3Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
4Internal Medicine, Faculty of medicine, Zagazig University
Abstract
Background: COVID-19 infection is commonly complicated by acute kidney injury (AKI) in up to 60-80 % of patients, however, data characterizing the severity and evolution of AKI, are limited. The aim of this study was to describe risk factors associated with AKI severity, in-hospital mortality, and short-term renal recovery in hospitalized COVID-19 patients.
Methods: A prospective cohort study that included Covid-19 patients, who developed AKI during hospitalization. Demographic, clinical, and laboratory data were recorded, and patients were followed up for 3 months.
Results: The study included 80 hospitalized COVID-19 patients who developed AKI. AKI stage 1, stage 2 and stage 3 occurred in 27(33.8%), 29(36.2%), and 24(30%) patients, respectively, whereas mortality was higher in stage 3 AKI (58.3%) compared to AKI stage 1(18.5%) and stage 2 (17.2%) p= 0.01. Of the 56 discharged patients, renal recovery occurred in AKI stage 1(100%), compared to AKI stage 2 (79%), and AKI stage 3 (50%). On multivariable analysis, age > 59 years, CKD, requiring dialysis, were associated with higher risk of mortality (Odd ratio: 1.9, 2.3, and 12.3, respectively). Conclusion: Stage 3 AKI patients had more ICU admissions, more patients required dialysis, less renal recovery, and higher mortality compared to AKI stage 1 and 2. CKD, age > 59 years, and requiring dialysis, were all independently associated with in-hospital mortality. After 3 months follow up renal recovery was the role in mild kidney injury; stage 1 AKI compared to stage 2 and 3.
Keywords
COVID-19; Acute kidney injury; AKI; mortality; renal recovery
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