The Synergistic Effect of Graphene / Carboxymethyl Cellulose/ Hydroxyapatite Nanocomposite on Controlled Drug Delivery | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 7, July 2023, Page 451-464 PDF (1.73 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.112368.5111 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
OTHMAN KHALIFI TAGHZOUTI1; Meriame Bricha2; Khalid Nouneh1; Anbalagan Balamurugan3; Khalil El Mabrouk   2
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| 1Eco-Campus, Meknes Road, Fès, Maroc | ||||
| 2Euromed Research Center, Euromed University of Fes, Eco-Campus, Fes, Morocco | ||||
| 3Dept of nanoscience and Technology Bharathiar University | ||||
| Abstract | ||||
| A new preparation method was reported to synthesize graphene GO - carboxymethyl cellulose CMC and hydroxyapatite HA (GO/CMC/HA). This new bio-nanocomposite was studied to control the loading and release cycle of amoxicillin drugs. The drug loading kinetics and release were studied with respect to the concentration of CMC of the drug carrier while keeping the concentration of GO and HA constant. The targeted delivery of amoxicillin was aimed at using these ternary nanocomposites. The evidence of functional groups and phase purity was analyzed using FTIR spectroscopy and X-ray diffraction techniques. The morphological features were studied using scanning electron microscopy. The thermal property of the developed materials was evaluated by thermogravimetric analysis (TGA). The elastic and storage modulus (G’ and G’’) as well as the complex viscosity (*) were recorded for the various concentration of CMC through rheological measurements. The efficiency of the drug delivery was studied using a diffusion mechanism. All the physico-chemical characterizations and rhological studies showed the efficacious synthesis of the new bio- nanocomposites GO/CMC/HA, through in situ precipitation and presents a good candidate to control the drug release applications. | ||||
| Keywords | ||||
| Carboxymethyl cellulose; Hydroxyapatite; Graphene oxide; drug delivery; Rheological measurements | ||||
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