Genetic Variants in ITPA and TNFSF10A Are Associated with the Risk of HCV Infection Among Egyptian Populations
Hassan, H., Neamatallah, M., Refaat, M., Youssef, M. (2023). Genetic Variants in ITPA and TNFSF10A Are Associated with the Risk of HCV Infection Among Egyptian Populations. EKB Journal Management System, 66(8), 85-93. doi: 10.21608/ejchem.2022.114930.5219
Hasnaa Hassan; Mostafa Neamatallah; Manar Refaat; Magdy Youssef. "Genetic Variants in ITPA and TNFSF10A Are Associated with the Risk of HCV Infection Among Egyptian Populations". EKB Journal Management System, 66, 8, 2023, 85-93. doi: 10.21608/ejchem.2022.114930.5219
Hassan, H., Neamatallah, M., Refaat, M., Youssef, M. (2023). 'Genetic Variants in ITPA and TNFSF10A Are Associated with the Risk of HCV Infection Among Egyptian Populations', EKB Journal Management System, 66(8), pp. 85-93. doi: 10.21608/ejchem.2022.114930.5219
Hassan, H., Neamatallah, M., Refaat, M., Youssef, M. Genetic Variants in ITPA and TNFSF10A Are Associated with the Risk of HCV Infection Among Egyptian Populations. EKB Journal Management System, 2023; 66(8): 85-93. doi: 10.21608/ejchem.2022.114930.5219

Genetic Variants in ITPA and TNFSF10A Are Associated with the Risk of HCV Infection Among Egyptian Populations

Egyptian Journal of Chemistry
Volume 66, Issue 8, August 2023, Page 85-93  XML PDF (637.4 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.114930.5219
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Authors
Hasnaa Hassan1; Mostafa Neamatallah2; Manar Refaat email 1; Magdy Youssef1
1Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
2Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Introduction: The liver is a unique organ in the human body. Many vital functions are attributed to it. Hepatitis C is one of the most diseases which intimidate liver integrity. ITPA is a human Inosine Triphosphate Pyrophosphatase ( ITPase ), which cleaves inosine triphosphate (ITP) and xanthine triphosphate (XTP) as well as their deoxyribose forms into monophosphates. Tumor necrosis factor receptor superfamily member 10A, is a cell surface receptor that bind to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and mediate the extrinsic pathway of apoptosis. Aim of the work: We aimed to clarify the association between the single nucleotide polymorphism of ITPA and TNFSF10A with the outcome of HCV infection. Subjects and method: a total of 264 subjects were recruited and classified into three main groups categorized as (I) spontaneous viral clearance (SVC) (N=55), (II)chronic HCV patients (CHCV) (N=106), and (III) control negative (N=103) where they were genotyped for SNP ITPA and TNFSF10A using allelic discrimination real-time PCR. Results: The carriage of the C allele of ITPA rs7270101 was significantly higher in HCV group compared to that of SVC (odds ratio [OR] 1.6176) and to that of controls (1.8447 ) (both P < 0.01) and carriage of C allele of TNFRSF10A (rs20575) was significantly higher in HCV group compared to that of SVC (odds ratio [OR] 2.1691 and to that of controls (2.1953 ). Conclusion: persistence of HCV infection is associated with C alleles of ITPA (rs7270101) and TNFRSF10A (rs20575) in Egyptian populations.
Keywords
Liver; Hepatitis C; DNA; Single nucleotide polymorphism; Real-time PCR
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