Therapeutic Potential of Radish Root Extract Against Doxorubicin-induced Cardiotoxicity in Male Rats Via Alleviating Disrupted Redox Homeostasis, Inflammation and Coagulation Activity
elwakf, A., El-Habibi, E., Abdel-Shafy, S., I. Ali, I., elmougy, R. (2023). Therapeutic Potential of Radish Root Extract Against Doxorubicin-induced Cardiotoxicity in Male Rats Via Alleviating Disrupted Redox Homeostasis, Inflammation and Coagulation Activity. EKB Journal Management System, 66(8), 13-23. doi: 10.21608/ejchem.2022.116972.5280
Azza elwakf; El-Sayed El-Habibi; Shaimaa Abdel-Shafy; Intisar I. Ali; rehab elmougy. "Therapeutic Potential of Radish Root Extract Against Doxorubicin-induced Cardiotoxicity in Male Rats Via Alleviating Disrupted Redox Homeostasis, Inflammation and Coagulation Activity". EKB Journal Management System, 66, 8, 2023, 13-23. doi: 10.21608/ejchem.2022.116972.5280
elwakf, A., El-Habibi, E., Abdel-Shafy, S., I. Ali, I., elmougy, R. (2023). 'Therapeutic Potential of Radish Root Extract Against Doxorubicin-induced Cardiotoxicity in Male Rats Via Alleviating Disrupted Redox Homeostasis, Inflammation and Coagulation Activity', EKB Journal Management System, 66(8), pp. 13-23. doi: 10.21608/ejchem.2022.116972.5280
elwakf, A., El-Habibi, E., Abdel-Shafy, S., I. Ali, I., elmougy, R. Therapeutic Potential of Radish Root Extract Against Doxorubicin-induced Cardiotoxicity in Male Rats Via Alleviating Disrupted Redox Homeostasis, Inflammation and Coagulation Activity. EKB Journal Management System, 2023; 66(8): 13-23. doi: 10.21608/ejchem.2022.116972.5280

Therapeutic Potential of Radish Root Extract Against Doxorubicin-induced Cardiotoxicity in Male Rats Via Alleviating Disrupted Redox Homeostasis, Inflammation and Coagulation Activity

Egyptian Journal of Chemistry
Volume 66, Issue 8, August 2023, Page 13-23  XML PDF (1.42 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.116972.5280
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Authors
Azza elwakf1; El-Sayed El-Habibi2; Shaimaa Abdel-Shafy1; Intisar I. Ali3; rehab elmougy email 4
1Zoology department, faculty of science, Mansoura university
2Zoology department, faulty of science, Mansoura university
3Emergency Hospital, Faculty of Medicine, Mansoura University, Egypt
4chemistry department, faculty of science,Mansoura university
Abstract
Cardiotoxicity is a major limiting factor for clinical use of doxorubicin (DOX) in chemotherapy. This study aimed to evaluate effectiveness of radish root extract (30mg/kg BW) to attenuate doxorubicin (DOX) - induced cardiotoxicity and to explore involved mechanisms. Phytochemical analysis of tested plant and assessment of antioxidant capacity against DPPH free radical were also performed. Treatment of male rats with DOX (2.5mg/kg BW, i.p.) twice weekly for 4 weeks elicited myocardial toxicity characterized by increased serum cTn-I, CK-MB, LDH and AST, decreased heart weight to body weight ratio, and myocardial degeneration. Other findings emphasized increased xanthine oxidase, lipid peroxidation, protein carbonyl, and nitric oxide, with diminished endogenous antioxidants in heart tissue, indicating provoked oxidative stress. Elevated serum inflammatory markers (TNF-α, CRP), adhesion molecules (VCAM-1, ICAM-1), fibrinogen and platelet activating factor, accompanied by marked thrombocytopenia were also validated. Results of radish analysis revealed strong scavenging activity against DPPH and presence of different polyphenols; flavonoids, tannins and alkaloids as a major phytoconstituents. Supplementation of radish extract has shown to be effective against toxic manifestations of DOX, most likely due to its radical scavenging and antioxidant activities. Therefore, radish extract can be suggested as a promising cardioprotective remedy for patients on DOX- based chemotherapy.
Keywords
Doxorubicin; cardiotoxicity; radish root extract; oxidative stress; adhesion molecules; platelet activating factor
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