Production and Evaluation of Fortified Biscuit with Iron Nanoparticles for Anemia as Functional Food | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 65, Issue 132, December 2022, Page 181-194 PDF (1.2 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.118578.5338 | ||||
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| Authors | ||||
Alaa G. Osman1, 2; Ahmed I. El-Desouky1; Mohamed K. Morsy   1; Ahmed A. Aboud3; Mahmoud H. Mohamed1
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| 1Department of Food Technology, Faculty of Agriculture, Benha University, Qaluobia, Egypt. | ||||
| 2Academy of Scientific Research and Technology (ASRT), Cairo, Egypt. | ||||
| 3Department of Physics, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. | ||||
| Abstract | ||||
| Biscuits are favored products for people of different ages world-wide due to its high-energy foods, long shelf-life, and easy absorption. This study aimed to evaluate the fortified biscuit with iron nanoparticles (Fe2O3-NPs) as novel approach to overcome iron deficiency anemia (IDA) disease. In preliminary experiments, we utilized 4 groups of albino rats as follows; negative group (G1; control), positive group (G2), treated anemic group (G3), and untreated anemic group (G4). The SEM, XRD, histopathological, and hematology tests were performed. The results revealed that the Fe2O3-NPs was at 49.5±5 nm, homogenous, and purity. Fortified biscuits with Fe2O3-NPs (10 ppm Fe2O3-NPs per 20g biscuit) increased the iron level (289±1.0 mg/dL), red blood counts (9.1±0.2 1012/L), and hemoglobin (18±0.25 g/dL) in the G3 compared to other groups. Histological examination showed that no significant effects on the spleen, kidney, and liver. Results demonstrated that the fortified biscuit with Fe2O3-NPs (10 ppm) at 49.5±5 nm is more effective in IDA treatment. | ||||
| Keywords | ||||
| iron deficiency anemia; nanoparticles; albino rats; hematology analysis; histopathological examination | ||||
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