Spectrophotometric Determination of Mesalazine via Diazotization-Coupling Reaction by Using Thymol Reagent | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 65, Issue 132, December 2022, Page 1561-1566 PDF (533.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.134639.5927 | ||||
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| Authors | ||||
Mohammed S. Al-Enizzi1; Intisar Adil Shihab Al-Hammoodi  2; Abdussamed M. Saeed3
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| 1Dept.of Chemistry, College of Education for girls, Mosul University, Iraq | ||||
| 2Department of Chemistry, college of Education for girls, University of Mosul , Mosul, Iraq | ||||
| 3Branch of Basic Science, College of Agriculture and Forestry, Mosul University, Iraq | ||||
| Abstract | ||||
| A simple and sensitive spectrophotometric method has been developed to determine Mesalazine in aqueous solution. The method depends on reaction of Mesalazine with thymol reagent to afford a colored analogue that has absorption band at 436 nm with molar absorptivity of 4149.95 L.mol-1.cm-1. The determination rang was 2-70 µg/ml with recovery 102.4 and relative standard of less than 1.5 %. The proposed method is applied for determination of Mesalazine in pharmaceutical preparation. | ||||
| Keywords | ||||
| Spectrophotometric; Mesalazine; Diazotization- coupling reaction; thymol | ||||
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