Synthesis of some new bis(pyrazol-5-ols), pyridones and benzo-[f]-thiochromene-2-carbonitrile derivatives bearing N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide moiety
Arafat, M., Khalifa, E., El-Taweel, F., Ayyad, S., Mohamed, K. (2022). Synthesis of some new bis(pyrazol-5-ols), pyridones and benzo-[f]-thiochromene-2-carbonitrile derivatives bearing N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide moiety. EKB Journal Management System, 12(1), 23-28. doi: 10.21608/sjdfs.2022.269870
Mahmoud Abdelhmid Arafat; Ehab Khalifa; Fathy El-Taweel; Seif-Eldin Ayyad; Khaled Samir Mohamed. "Synthesis of some new bis(pyrazol-5-ols), pyridones and benzo-[f]-thiochromene-2-carbonitrile derivatives bearing N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide moiety". EKB Journal Management System, 12, 1, 2022, 23-28. doi: 10.21608/sjdfs.2022.269870
Arafat, M., Khalifa, E., El-Taweel, F., Ayyad, S., Mohamed, K. (2022). 'Synthesis of some new bis(pyrazol-5-ols), pyridones and benzo-[f]-thiochromene-2-carbonitrile derivatives bearing N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide moiety', EKB Journal Management System, 12(1), pp. 23-28. doi: 10.21608/sjdfs.2022.269870
Arafat, M., Khalifa, E., El-Taweel, F., Ayyad, S., Mohamed, K. Synthesis of some new bis(pyrazol-5-ols), pyridones and benzo-[f]-thiochromene-2-carbonitrile derivatives bearing N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide moiety. EKB Journal Management System, 2022; 12(1): 23-28. doi: 10.21608/sjdfs.2022.269870

Synthesis of some new bis(pyrazol-5-ols), pyridones and benzo-[f]-thiochromene-2-carbonitrile derivatives bearing N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide moiety

Scientific Journal for Damietta Faculty of Science
Volume 12, Issue 1, 2022, Pages 23-28    PDF (374.29 K)
Document Type: Original articles
DOI: 10.21608/sjdfs.2022.269870
Authors
Mahmoud Abdelhmid Arafat* 1; Ehab Khalifa2; Fathy El-Taweel3; Seif-Eldin Ayyad4; Khaled Samir Mohamed5
1Department of Chemistry, Faculty of Science, Damietta Univesity, New Damietta, Egypt.
2Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
3Department of Chemistry, Faculty of Science, New Damietta City, Damietta University, Egypt
4Department of Chemistry, Faculty of Science, Damietta University, New Damietta, Egypt
5Engineering Chemistry Department, Higher Institute for Engineering and Technology, New Damietta, Egypt
Abstract
Abstract. Novel 4,4 ′- ( arylmethylene ) - bis(3 - methyl -1- phenyl-1H-pyrazol - 5 - ol) derivative 2 was synthesized via interaction of N - ( 4 - chlorophenyl ) - 2 - (4 - formylphenoxy) acetamide (1) with diverse available reagent (two mole from 3 - methyl -1H -pyrazol - 5(4 H) -one). Moreover, One - pot pseudo three-component reaction of hydrazine hydrate, ethyl acetoacetate and aldehydes in ethanole using pipridine at 70°C afforded the corresponding aminopyrazole derivative 3. on the other hand, cyanoacetamide scaffolds 4a,b was reacted with aromatic aldehyde particularly N -( 4 -chlorophenyl ) - 2 - (4 -formylphenoxy) acetamide (1), to afford arylidenes 5 a, b that undergoes cyclization by heating in ethanol containing drops of piperidine as catalyst, and malononitrile afforded the corresponding pyridinone derivatives 6 a,b. All freshly synthesized scaffolds were elucidated by considering the data of both elemental and spectral analyses.
Keywords
Keywords. N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide; bis(pyrazol-5-ols); pyridones and benzo-[f]-thiochromene-2-carbonitrile
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