LYCOPENE AMELIORATES OVARIAN FOLLICULAR MATURATION IN RAT MODEL OF POLYCYSTIC OVARIAN SYNDROME: A HISTOMORPHOLOGICAL AND FUNCTIONAL STUDY | ||||
| Egyptian Journal of Histology | ||||
| Articles in Press, Accepted Manuscript, Available Online from 15 November 2022 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2022.167869.1788 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Minahil Haq   1; Shabana Ali2; Maria yousaf3
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| 1Riphah Islamic International Medical College | ||||
| 2Riphah International Islamic University islamabad | ||||
| 3Riphah international Islamic University Islamabad | ||||
| Abstract | ||||
| Abstract Background and aims: Polycystic ovarian syndrome is a menacing metabolic condition with high prevalence rate in Asian countries involving women of reproductive age. This study was commenced to asses favorable effects of lycopene—a dietary component in letrozole induced PCOS rat model. Methods: Fifty adult female Sprague Dawley rats were divided into five groups, ten rats each for a study of 5weeks. Control group A was given standard rat diet. Rats of experimental group B were given 1mg/kg of letrozole to induce PCO model. Group C was given 1mg/kg of letrozole+15mg/kg/day of lycopene. Group D was given 1mg/kg of letrozole+ 500 mg/kg/day metformin. Group E was given 1mg/kg of letrozole +combination of lycopene and metformin together. Relative body weight was taken on day1 and end of experiment. Antioxidant activity was tested using CAT, SOD and MDA . Ovaries were removed for H&E staining and studied under light microscopy. Statical analysis was carried out for result interpretations. Results: The results showed, restoration of rat weight back to normal by use of lycopene. Histological architecture of ovary showed better count of secondary and graafian follicles towards normal values which was quite reduced in group B proved by significant p-value | ||||
| Keywords | ||||
| lycopene; letrozole; PCOS; oxidative stress | ||||
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