Acute-on-Chronic Liver Failure in Zagazig University Hospital: A Single Center-Based Study | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 99, Volume 89, Issue 2, October 2022, Page 6734-6742 PDF (568.64 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.270769 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ayman Yousef Ahmed Mohamed Eltaweel; Emad Abdullatif Emam; Salem Youssef Mohamed | ||||
| Abstract | ||||
| Background : Chronic or acute liver failure is a common condition that has a number of contributing variables; a high death rate and a dismal prognosis. The mainstay of these individuals' survival chances is liver transplantation. Objectives: To identify the prevalence of acute-on-chronic liver failure (ACLF) and to characterize patients admitted with ACLF according to the European association for the study of liver (EASL) definition of ACLF to determine the possible risk and precipitating factors and show the outcomes. Patients and Method: Prospective study in a single tertiary University hospital was conducted for 1 year duration, comparing cirrhotic patients with or without ACLF according to EASL-ACLF criteria. Results: The prevalence rate of ACLF was 57.9% of the studied populations. GIT bleeding, HE, and active infections were the most frequent precipitating factors. Patients who have ACLF had a high 28-day mortality rate (67.3%). The rate of mortality was significantly greater with the grade of ACLF. Chronic liver failure (CLIF) score of more than 5 was associated with 86.84% sensitivity, 45.95% specificity, 63% negative predictive value, 76.7% positive predictive value as well as 0.661 AUC. Conclusion: A common illness with a high death rate is ACLF. The primary triggering causes include GIT hemorrhage, HE, and active infection. High sensitivity and positive predictive value, but low specificity and negative predictive value are associated with a CLIF score of more than five for mortality in ACLF patients. | ||||
| Keywords | ||||
| ACLF; Decompensated cirrhosis; Mortality | ||||
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