Potential Role of Circulating Dermokine and Bcl-2 Anti-apoptotic Protein in Colorectal Cancer Egyptian Patients: Correlative Analysis with the Clinicopathological Parameters
Abdelsamea, S., El-Emshaty, H., Othman, O., El-Hemaly, M., Ismail, H. (2022). Potential Role of Circulating Dermokine and Bcl-2 Anti-apoptotic Protein in Colorectal Cancer Egyptian Patients: Correlative Analysis with the Clinicopathological Parameters. EKB Journal Management System, 8(4), 307-318. doi: 10.21608/jbaar.2022.270833
Shaimaa M. Abdelsamea; Hoda M. El-Emshaty; Othman A. Othman; Mohamed M. El-Hemaly; Hisham Ismail. "Potential Role of Circulating Dermokine and Bcl-2 Anti-apoptotic Protein in Colorectal Cancer Egyptian Patients: Correlative Analysis with the Clinicopathological Parameters". EKB Journal Management System, 8, 4, 2022, 307-318. doi: 10.21608/jbaar.2022.270833
Abdelsamea, S., El-Emshaty, H., Othman, O., El-Hemaly, M., Ismail, H. (2022). 'Potential Role of Circulating Dermokine and Bcl-2 Anti-apoptotic Protein in Colorectal Cancer Egyptian Patients: Correlative Analysis with the Clinicopathological Parameters', EKB Journal Management System, 8(4), pp. 307-318. doi: 10.21608/jbaar.2022.270833
Abdelsamea, S., El-Emshaty, H., Othman, O., El-Hemaly, M., Ismail, H. Potential Role of Circulating Dermokine and Bcl-2 Anti-apoptotic Protein in Colorectal Cancer Egyptian Patients: Correlative Analysis with the Clinicopathological Parameters. EKB Journal Management System, 2022; 8(4): 307-318. doi: 10.21608/jbaar.2022.270833

Potential Role of Circulating Dermokine and Bcl-2 Anti-apoptotic Protein in Colorectal Cancer Egyptian Patients: Correlative Analysis with the Clinicopathological Parameters

Journal of Bioscience and Applied Research
Volume 8, Issue 4, December 2022, Page 307-318  XML PDF (435.27 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2022.270833
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Authors
Shaimaa M. Abdelsamea1; Hoda M. El-Emshaty email 2; Othman A. Othmanorcid 1; Mohamed M. El-Hemaly3; Hisham Ismail1
1Biochemistry Division, Chemistry Dept., Faculty of Science, Minia University, Minia 61519, Egypt
2Gastrointestinal surgical center - Mansoura university - Mansoura - Egypt
3Gastrointestinal Surgery Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
Abstract
Colorectal cancer (CRC) is the seventh most common cancer in Egypt, and more than half of the patients are under the age of 50. Here, we aimed to assess the levels of circulating Dermokine (DMKN) and cytoplasmic anti-apoptotic protein, Bcl-2 for detecting CRC in the earlier stages possible. The levels of DMKN, Bcl-2, Carcinoembryonic antigen (CEA), and Carbohydrate antigen 19.9 were determined using ELISA in the sera of 53 CRC patients, 18 ulcerative colitis patients, and 24 healthy individuals. Statistical analyses were performed using the SPSS program. Serum levels of DMKN and Bcl-2 were significantly higher (p < 0.0001) in CRC patients than in non-cancer individuals. Highly significant correlations were recorded between levels of DMKN and Bcl-2 and the pathological TNM tumor characteristics. At the best cut-off level (68-pg/mL), the DMKN assay showed high degrees of sensitivity (87%), specificity (100%), and accuracy (91%) in comparison with investigated biomarkers. Furthermore, regression analysis revealed a DKB-Score based on DMKN and Bcl-2 with an AUROC of 0.991. The developed score showed a high degree of efficiency (97.4%) for discriminating CRC patients from controls. In conclusion, the assessment of serum DMKN either alone or simultaneously with Bcl-2 has a potential role in discriminating CRC from premalignant patients.
Keywords
Dermokine; Bcl-2; Ulcerative colitis; Colorectal cancer; Egypt
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