A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS
Abushammala, I., Hamdan, A. (2022). A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS. EKB Journal Management System, 45(2), 493-506. doi: 10.21608/bfsa.2022.271394
Issam Mohammed Abushammala; Abdallah Mohammed Hamdan. "A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS". EKB Journal Management System, 45, 2, 2022, 493-506. doi: 10.21608/bfsa.2022.271394
Abushammala, I., Hamdan, A. (2022). 'A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS', EKB Journal Management System, 45(2), pp. 493-506. doi: 10.21608/bfsa.2022.271394
Abushammala, I., Hamdan, A. A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS. EKB Journal Management System, 2022; 45(2): 493-506. doi: 10.21608/bfsa.2022.271394

A REVIEW OF THEOPHYLLINE'S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS

Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2, December 2022, Page 493-506  XML PDF (823.17 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.271394
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Authors
Issam Mohammed Abushammala email orcid ; Abdallah Mohammed Hamdanorcid
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al- Azhar University- Gaza, P.O Box: 1277, Gaza, Palestine.
Abstract
Theophylline (TPH) is a bronchodilator with a limited therapeutic index and high inter-individual pharmacokinetic (PK) variability. In this paper, the interactions between TPH and medicinal herbs recorded in the literature were summarized.  The  collected references in the analyzed literature were investigated. A decrease in TPH bioavailability by induction mechanism on CYP1A2 was reported during co-administration of herbs or herbal extracts as (Andrographis paniculata, Commiphora myrrha, Ephedra species, Evodia rutaecarpa, Lepidium sativum, Sophora flavescens, Salvia miltiorrhiza, and Trigonella foenum-graecum). TPH bioavailability was increased by inhibition mechanism on CYP1A2 when co-administered with herbs (Acacia catechu, Angelica species, Astragalus species, Cassia auriculata, Cardiospermum halicacabum  and  Scutellariae baicalensis. Meanwhile, concomitant use of TPH with (Cassia occidentalis, Glycyrrhiza glabra, Ginkgo biloba, Hypericum perforatum, Nigella sativa, Punica granatum and Rhodiola rosea) was reported to be insignificant. In this review, we focus on the interactions between TPH and medicinal herbs that haven't been covered in prior studies. To reduce the patients' health risks, health professionals involved in their treatment are expected to be thoroughly educated about the interactions between TPH and medicinal plants.
Keywords
Theophylline; Herb-Drug Interaction; CYP1A2; Pharmacology; Bioavailability
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