EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES
Pathan, S., Patil, R., Sangshetti, J. (2022). EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES. EKB Journal Management System, 45(2), 685-693. doi: 10.21608/bfsa.2022.271592
Shahebaaz K. Pathan; Rajendra H. Patil; Jaiprakash N. Sangshetti. "EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES". EKB Journal Management System, 45, 2, 2022, 685-693. doi: 10.21608/bfsa.2022.271592
Pathan, S., Patil, R., Sangshetti, J. (2022). 'EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES', EKB Journal Management System, 45(2), pp. 685-693. doi: 10.21608/bfsa.2022.271592
Pathan, S., Patil, R., Sangshetti, J. EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES. EKB Journal Management System, 2022; 45(2): 685-693. doi: 10.21608/bfsa.2022.271592

EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES

Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2, December 2022, Page 685-693  XML PDF (669.26 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.271592
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Authors
Shahebaaz K. Pathanorcid 1; Rajendra H. Patilorcid 2; Jaiprakash N. Sangshetti email orcid 1
1Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad- (MS) India
2Department of Biotechnology, Savitribai Phule Pune University, Pune 4110007
Abstract
The emergence of resistance in the immunocompromised patients against existing anticandidal agents makes them ineffective causing high incidence and accompanying mortality due to the fungal infections. The generation of biofilms by various species of candida is the most frequent underlying mechanism in the emergence of resistance. Biofilms are defined as encapsulated complex microbial colonies in extracellular polymeric substances (EPS) matrix. The development of newer anticandidal with lower resistance remains a challenging task for researchers. We herein report, a series of N-(substituted benzylidene)-4,6-dimethoxypyrimidin-2-amine analogs along with their antibiofilm and anticandidal potential in-vitro. Compounds 3a, 3b, 3i, 3k, and 3l have shown better inhibition against C. albicans than Fluconazole (standard anticandidal agent). Compounds 3a, 3b, and 3i also exhibited good antibiofilm activity suggesting their antibiofilm as well as anticandidal potential. The results show that the new compounds could serve as an important lead in the discovery of effective anticandidal agents to overcome the resistance problem associated with the existing anticandidal agents.
Keywords
Pyrimidine Schiff bases; Anticandidal activity; Antifungal; Antibiofilm
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