EVALUATION OF CURRENT PRACTICE OF STRESS ULCER PROPHYLAXIS IN PATIENTS ADMITTED TO INTENSIVE CARE UNITS IN THE GAZA STRIP- PALESTINE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 45, Issue 2, December 2022, Page 845-857 PDF (764.76 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2022.271660 | ||||
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| Authors | ||||
Hala Zl Alagha   1; Nasaem Ramadan Mohammed Al Mabhouh2
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| 1Department of pharmacology and medical sciences- Faculty of pharmacy- Al Azhar University -Gaza -Palestine | ||||
| 2Department of Pharmacology and Medical Sciences, Faculty of Pharmacy, Al Azhar University of Gaza, Palestine P.O Box: 1277 | ||||
| Abstract | ||||
| This study aimed at assessing the degree of adherence of Stress ulcer prophylaxis (SUP) practice to the American Society of Health-System Pharmacists (ASHP) guidelines in intensive care units (ICUs) at three hospitals in the Gaza Strip, Palestine. This was a prospective study that utilized chart review methodology for data collection. Four aspects of SUP practice were assessed: indication, dose, route of administration and duration. The study enrolled 442 ICU patients with a median (Interquartile range, IQR) age of 49.0 (36.6) years. More than half the patients (55.7%) were males. Coagulopathy was the most common major risk factor for stress ulcer, presented in 73 (16.5%) patients, while the use of corticosteroid therapy was the most common minor risk factor presented in 93 (21%) patients. SUP was administered to 426 (96.4%) patients, of which 86.9% received ranitidine and 13.1% received PPIs. Overall adherence and indication adherence rates to guidelines were 16.7% and 36.4%, respectively. Appropriate dose, route and duration of SUP were found in 63.6%, 68.2%, and 88.1% of the evaluated doses, respectively. Of the 426 patients prescribed SUP, 48 (11.3%) developed adverse effects. This study revealed suboptimal SUP practice in the investigated hospitals and the need to apply strategies to improve SUP use patterns. | ||||
| Keywords | ||||
| Stress ulcer; ASHP guidelines; prophylaxis; Intensive care unit; Adherence | ||||
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