ASSESSMENT OF NEW PREDICTING BIOMARKERS OF POLLUTION TOXICITY IN WORKERS OR INDIVIDUALS LIVING CLOSE TO OIL REFINERY AREA IN AL-MUTHANNA CITY, IRAQAS ALARM INDICATORS FOR CLINICAL DISORDERS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 45, Issue 2, December 2022, Page 883-893 PDF (1.11 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2022.271691 | ||||
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| Authors | ||||
| Mariam Ryadh Alghara1; Ausama Ayob Jaccob* 2; Azza Sajid Jabbar3 | ||||
| 1BSC in pharmacy, AL Muthanna Health Department, Planning Department, al Muthanna, Iraq | ||||
| 2Department of Pharmacology and Toxicology, College of Pharmacy, Basra University, Basra, Iraq | ||||
| 3Department of Physiology, College of pharmacy, Basra University, Basra, Iraq | ||||
| Abstract | ||||
| Objective, This study aims to assess the impact of petroleum exposure on certain biochemical parameters; to find out the sensitive predicting biomarkers which may be considered of a clinical role in detecting the toxic effect of exposure as well as to conclude the possible correlation among the parameters.Methods, 150 individuals were enrolled in this study. The participants were separated into three groups: Group 1 is a control group of 50 people; Group2 is 50 people (who were oil well workers); and Group3 is 50 people (the individuals who live close to oil wells), working in the Middle Refinery Company unit for more than two years. The hematological parameters, serum interleukin 6, serum vitamin D3, serum homocysteine, and serum glutathione were all measured. Results showed significant increases in white blood cells,and platelets in Group2 and Group3 compared to Group1as well as a significant decrease of hemoglobin, hematocrit, and glutathione in workers compared to control groups. Interestingly, we found significant increases in serum interleukin 6 and homocysteine in workers. Conclusions, The individuals who work or live close to oil wells showed significant alterations in some hematological, immunological, and inflammatory parameters,as well as they, revealed more production of reactive oxygen species referring to an increase in oxidative stress. | ||||
| Keywords | ||||
| Oil wells; air pollution toxicity; predicting biomarkers | ||||
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