STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS
Radwan, S., El Wessemy, A., Abdel-Aziz, B., Abdel-Baky, E. (2022). STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS. EKB Journal Management System, 45(2), 903-913. doi: 10.21608/bfsa.2022.271769
Shadia A. Radwan; Aziza M. El Wessemy; Basma F. Abdel-Aziz; Enas S. Abdel-Baky. "STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS". EKB Journal Management System, 45, 2, 2022, 903-913. doi: 10.21608/bfsa.2022.271769
Radwan, S., El Wessemy, A., Abdel-Aziz, B., Abdel-Baky, E. (2022). 'STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS', EKB Journal Management System, 45(2), pp. 903-913. doi: 10.21608/bfsa.2022.271769
Radwan, S., El Wessemy, A., Abdel-Aziz, B., Abdel-Baky, E. STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS. EKB Journal Management System, 2022; 45(2): 903-913. doi: 10.21608/bfsa.2022.271769

STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS

Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2, December 2022, Page 903-913  XML PDF (793.67 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.271769
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Authors
Shadia A. Radwan; Aziza M. El Wessemy; Basma F. Abdel-Aziz; Enas S. Abdel-Baky email
Biological and Geological Sciences Departmen, Faculty of Education, Ain Shams University, Cairo, Egypt
Abstract
The current investigation was carried out to study the protective effect of vitamin E (VE) on the associated disturbances of hematological, renal, and hepatic functions in male rats produced in potassium bromate (KBrO3) treated rats. Twenty-four rats were divided randomly into four groups: First group: served as control group. Second group: rats were received 50 mg/kg b.wt. of KBrO3 orally. Third group: rats were received 30 mg/kg b.wt. of VE orally. Fourth group: rats were received 30 mg/kg b.wt. of VE orally an hour before administration of KBrO3 (50 mg/kg b.wt.) orally. The experiment continued for five successive weeks. Results showed that the treatment with KBrO3 revealed a significantly decrease in the mean of the body weight, red blood corpuscles (RBCs), white blood cells (WBCs), blood platelets (PLTs), hemoglobin (HB), hematocrit value (HCT) comparing to the control group. Whereas, the serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes, urea, uric acid, creatinine, were obviously elevated in KBrO3 treated group comparing with control group. The treatment with VE+KBrO3 ameliorated all the hematological, renal, and hepatic parameters tested. It is clear from the present results that VE reduced the severity of KBrO3. This could be mediated by its potent antioxidant effects.
 
Keywords
Potassium bromate; Vitamin E; Hematological; Renal; Hepatic functions
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