EFFICACY OF OLMESARTAN, IRBESARTAN AND TELMISARTAN AGAINST ACUTE INDOMETHACIN-INDUCED GASTRIC ULCERS IN MICE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 45, Issue 2, December 2022, Page 1005-1012 PDF (941.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2022.271786 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sara Khallouf  1; Rana Makhous1; Rana Issa2
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| 1Pharmacology & Toxicology Department, Faculty of Pharmacy, Tishreen University, Lattakia, Syria | ||||
| 2Pathology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria | ||||
| Abstract | ||||
| Recent studies have determined detrimental effects of angiotensin-II in gastric mucosa. This study aims to investigate the gastroprotective role of some Angiotensin-II receptor blockers (ARBs): olmesartan, irbesartan and telmisartan on indomethacin-induced gastric ulcers in mice. Also, it provides a new comparison to know if the agonist action of peroxisome proliferator-activated receptor gamma (PPAR-γ) involves in protecting gastric mucosa; if found. Animals were divided into six groups (n= 9 in each); group 1 (normal control), group 2 (non-pretreated, induced-ulcer), group 3 (olmesartan 8.2 mg/kg), group 4 (irbesartan 61.5 mg/kg), group 5 (telmisartan 16.4 mg/kg), group 6 (ranitidine 61.5 mg/kg). Drugs were given orally for 15 days; then gastric ulcers were induced by a single oral dose of indomethacin (250 mg/kg). Histological findings showed that these members of ARBs decreased the depth of ulcers but without significant difference between them. Their gastroprotective effects were not comparable to ranitidine effect. We need further researches, and recommend studying the effect of ARBs in combination with anti-ulcer drugs. | ||||
| Keywords | ||||
| angiotensin-II; gastroprotective; ARBs; PPAR- γ; gastric ulcers; indomethacin | ||||
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