PHARMACOLOGICAL EVALUATION OF NOOTROPIC AND NEUROPROTECTIVE ACTIVITY OF SESBANIA GRANDIFLORA EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC MODEL OF RATS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 45, Issue 2, December 2022, Page 1063-1076 PDF (1.3 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2022.271820 | ||||
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| Authors | ||||
| Jagadeeshwar Kolguri1; Subhakara Raju Rapaka1; Rajasekhar Reddy Alavala* 2; Koteswara Rao GSN1; Shireesha Boyapati3; Raghavendra Kumar Gunda4 | ||||
| 1K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502 | ||||
| 2K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502 -Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai- 400056, India | ||||
| 3Department of Pharmaceutical Chemistry, Telangana University, Nizamabad, Telangana, India-503322 | ||||
| 4Department of Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, India-522213 | ||||
| Abstract | ||||
| Background: Diabetes Mellitus (DM) is a multifactorial disorder and is frequently correlated with chronic problems associated with various major organs. In recent times, there has been some correlations reported about the neurological complications of DM, such as cognitive impairment, vascular dementia, stroke, or depression. and observed that the brain tissue of the diabetic patients with hyperglycemia have shown injury at various locations with a varied profile of micro and macrostructural changes, which leads to the neurodegeneration, neuro-vascular deterioration, neuro-inflammation, and progressive cognition decline. Aim: The current study assesses memory enhancing activity of Sesbania grandiflora (SG) extracts in streptozotocin (STZ)-induced diabetic model in rat. Methods: The extracts (petroleum ether, ethyl acetate and methanol) were analyzed for acute toxicity and later its neuroprotective and memory enhancing activity in the selected rat model. STZ (55 mg/kg) injection was administered intraperitoneally to the animals to induce memory impairment. SG extracts were administered for 70 days after confirming STZ-induced dementia to detect its beneficial effect. To know the memory function the animals were subjected to Y-maze and Morris water maze test. After the tests, the animals were sacrificed and performed cholinergic function and oxidative stress with the brain tissue. Results: It was observed that STZ caused significant memory impairment, which was significantly reversed by methanolic extract with 100 and 200 mg/kg. It was found that the cholinergic dysfunction, rise in lipid peroxidation levels were significantly (p<0.001) reduced. In the diabetic induced group, it was identified that there was a radical reduction of glutathione, superoxide dismutase, and catalase activities than the control group animals. Conclusion: The current investigation established that SG leaf extracts improve the memory by enhancing the cholinergic transmission and reducing the oxidative stress in the brain of diabetic rats. | ||||
| Keywords | ||||
| Diabetes; dementia; cholinergic dysfunction; oxidative stress and Sesbania grandiflora | ||||
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