IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Volume 45, Issue 2, December 2022, Page 1085-1096 PDF (1.22 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2022.271822 | ||||
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Authors | ||||
Sherif ElSherbini1; Abada AbdAlRaouf1; Samir El-Masry1; Adel Abdelsalam2; Maged Mostafa 3 | ||||
1Molecular Biology Department, Genetic Engineering and Biotechnology Institute, Sadat City University, Egypt | ||||
2Internal Medicine Department, Rheumatology & Immunology Unit, Mansoura Faculty of Medicine, Mansoura University, Egypt | ||||
3Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt | ||||
Abstract | ||||
Systemic Lupus erythematosus (SLE) is a worldwide autoimmune disease with different presentations. Genetic and environmental factors like infection and ultraviolet light are supposed to be responsible for the development of SLE. Disturbance in cytokines production may be involved in SLE pathogenesis. In this case-control study, we investigate the interleukin-17F (IL-17F) gene polymorphism (7488T/C, rs763780) in Egyptian SLE patients using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). There were no significant changes when both genotypes and alleles for patients and controls were compared with each other. According to the results, no association between the IL-17F gene polymorphism (7488T/C, rs763780) and SLE. | ||||
Keywords | ||||
SLE; IL-17F; Cytokine; autoimmune | ||||
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