IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE
ElSherbini, S., AbdAlRaouf, A., El-Masry, S., Abdelsalam, A., Mostafa, M. (2022). IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE. EKB Journal Management System, 45(2), 1085-1096. doi: 10.21608/bfsa.2022.271822
Sherif ElSherbini; Abada AbdAlRaouf; Samir El-Masry; Adel Abdelsalam; Maged Mostafa. "IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE". EKB Journal Management System, 45, 2, 2022, 1085-1096. doi: 10.21608/bfsa.2022.271822
ElSherbini, S., AbdAlRaouf, A., El-Masry, S., Abdelsalam, A., Mostafa, M. (2022). 'IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE', EKB Journal Management System, 45(2), pp. 1085-1096. doi: 10.21608/bfsa.2022.271822
ElSherbini, S., AbdAlRaouf, A., El-Masry, S., Abdelsalam, A., Mostafa, M. IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE. EKB Journal Management System, 2022; 45(2): 1085-1096. doi: 10.21608/bfsa.2022.271822

IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE

Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2, December 2022, Page 1085-1096  XML PDF (1.22 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.271822
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Authors
Sherif ElSherbini1; Abada AbdAlRaouf1; Samir El-Masry1; Adel Abdelsalam2; Maged Mostafa email orcid 3
1Molecular Biology Department, Genetic Engineering and Biotechnology Institute, Sadat City University, Egypt
2Internal Medicine Department, Rheumatology & Immunology Unit, Mansoura Faculty of Medicine, Mansoura University, Egypt
3Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt
Abstract
Systemic Lupus erythematosus (SLE) is a worldwide autoimmune disease with different presentations. Genetic and environmental factors like infection and ultraviolet light are supposed to be responsible for the development of SLE. Disturbance in cytokines production may be involved in SLE pathogenesis. In this case-control study, we investigate the interleukin-17F (IL-17F) gene polymorphism (7488T/C, rs763780) in Egyptian SLE patients using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). There were no significant changes when both genotypes and alleles for patients and controls were compared with each other. According to the results, no association between the IL-17F gene polymorphism (7488T/C, rs763780) and SLE.
 
Keywords
SLE; IL-17F; Cytokine; autoimmune
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