Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms
Sehim, A., Abdel-Ghafar, R., Hamza, Z., El-Nekeety, A., ِAbdel-Wahhab, M. (2023). Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms. EKB Journal Management System, 66(8), 383-392. doi: 10.21608/ejchem.2022.160916.6926
Amira E. Sehim; Rasha Y. Abdel-Ghafar; zeinab khaaled Hamza; Aziza A. El-Nekeety; Mossad ِAttia ِAbdel-Wahhab. "Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms". EKB Journal Management System, 66, 8, 2023, 383-392. doi: 10.21608/ejchem.2022.160916.6926
Sehim, A., Abdel-Ghafar, R., Hamza, Z., El-Nekeety, A., ِAbdel-Wahhab, M. (2023). 'Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms', EKB Journal Management System, 66(8), pp. 383-392. doi: 10.21608/ejchem.2022.160916.6926
Sehim, A., Abdel-Ghafar, R., Hamza, Z., El-Nekeety, A., ِAbdel-Wahhab, M. Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms. EKB Journal Management System, 2023; 66(8): 383-392. doi: 10.21608/ejchem.2022.160916.6926

Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms

Egyptian Journal of Chemistry
Volume 66, Issue 8, August 2023, Page 383-392  XML PDF (1.2 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.160916.6926
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Authors
Amira E. Sehim1; Rasha Y. Abdel-Ghafar1; zeinab khaaled Hamzaorcid 2; Aziza A. El-Nekeety3; Mossad ِAttia ِAbdel-Wahhab email orcid 4
1Botany and Microbiology Dept, Faculty of Science; Benha University, Benha, Egypt
2Food Toxicology & Contaminants Dept., National Research Centre, Cairo, Egypt
3Food Toxicology & Contaminants Dept., National Research Center
4Department of Food Toxicology & Contaminants. National Research Center ·
Abstract
Curcumin (Cur) is a pivotal compound widely used in pharmaceutical and medical applications such as antioxidant, antimicrobial, anticancer, and anti-inflammatory. However, some limitations faced its application in different purposes owing to its insolubility, low bioavailability, and fast degradation. These limitations can be overcome by the formulation of Cur nanoparticles (Cur-NPs) to boost its bioactivity and enhance its solubility. This study aimed to synthesize and characterize Cur-NPs and evaluate the antioxidant activity and antimicrobial efficiency against different pathogenic microorganisms. Cur-NPs were prepared, characterized and the antimicrobial efficiency was evaluated against E. coli, S. typhimurium, and Y. enterocolitica (Gram-negative), S. aureus, B. cereus (Gram-positive), and the pathogenic fungi (Aspergillus niger, A flavus, Penicillium expansum, and Candida albicans). The synthesized Cur-NPs showed a rounded shape with 44 ± 8 nm average size and 43 ± 4 mV ξ-potential. Cur-NPs showed potent antioxidant (IC50 of 1550 µg/ml) and antimicrobial properties against the tested bacteria and fungi in a dose-dependent manner. It could be concluded that Cur-NPs are a promising candidate to be used as an antimicrobial in food preservation, or medical and pharmaceutical applications to replace antibiotics.
Keywords
Curcumin nanoparticles; antioxidant; antibacterial; antifungal; antimicrobial
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