Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms | ||||
Egyptian Journal of Chemistry | ||||
Volume 66, Issue 8, August 2023, Page 383-392 PDF (1.2 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2022.160916.6926 | ||||
View on SCiNiTO | ||||
Authors | ||||
Amira E. Sehim1; Rasha Y. Abdel-Ghafar1; zeinab khaaled Hamza 2; Aziza A. El-Nekeety3; Mossad ِAttia ِAbdel-Wahhab 4 | ||||
1Botany and Microbiology Dept, Faculty of Science; Benha University, Benha, Egypt | ||||
2Food Toxicology & Contaminants Dept., National Research Centre, Cairo, Egypt | ||||
3Food Toxicology & Contaminants Dept., National Research Center | ||||
4Department of Food Toxicology & Contaminants. National Research Center · | ||||
Abstract | ||||
Curcumin (Cur) is a pivotal compound widely used in pharmaceutical and medical applications such as antioxidant, antimicrobial, anticancer, and anti-inflammatory. However, some limitations faced its application in different purposes owing to its insolubility, low bioavailability, and fast degradation. These limitations can be overcome by the formulation of Cur nanoparticles (Cur-NPs) to boost its bioactivity and enhance its solubility. This study aimed to synthesize and characterize Cur-NPs and evaluate the antioxidant activity and antimicrobial efficiency against different pathogenic microorganisms. Cur-NPs were prepared, characterized and the antimicrobial efficiency was evaluated against E. coli, S. typhimurium, and Y. enterocolitica (Gram-negative), S. aureus, B. cereus (Gram-positive), and the pathogenic fungi (Aspergillus niger, A flavus, Penicillium expansum, and Candida albicans). The synthesized Cur-NPs showed a rounded shape with 44 ± 8 nm average size and 43 ± 4 mV ξ-potential. Cur-NPs showed potent antioxidant (IC50 of 1550 µg/ml) and antimicrobial properties against the tested bacteria and fungi in a dose-dependent manner. It could be concluded that Cur-NPs are a promising candidate to be used as an antimicrobial in food preservation, or medical and pharmaceutical applications to replace antibiotics. | ||||
Keywords | ||||
Curcumin nanoparticles; antioxidant; antibacterial; antifungal; antimicrobial | ||||
Statistics Article View: 217 PDF Download: 107 |
||||