Comparing The Efficacy and Safety of (Ombitasvir/ Paritaprevir/ Ritonavir) in Management of Chronic HCV Patients Among Haemodialysis Patients and Those with Normal Renal Functions
Mahmoud, A., El Ameen, H., Mostafa, N. (2022). Comparing The Efficacy and Safety of (Ombitasvir/ Paritaprevir/ Ritonavir) in Management of Chronic HCV Patients Among Haemodialysis Patients and Those with Normal Renal Functions. EKB Journal Management System, 89(2), 6889-6894. doi: 10.21608/ejhm.2022.271907
Alaa Ahmed Mahmoud; Hussein El Ameen; Nashwa Mostafa. "Comparing The Efficacy and Safety of (Ombitasvir/ Paritaprevir/ Ritonavir) in Management of Chronic HCV Patients Among Haemodialysis Patients and Those with Normal Renal Functions". EKB Journal Management System, 89, 2, 2022, 6889-6894. doi: 10.21608/ejhm.2022.271907
Mahmoud, A., El Ameen, H., Mostafa, N. (2022). 'Comparing The Efficacy and Safety of (Ombitasvir/ Paritaprevir/ Ritonavir) in Management of Chronic HCV Patients Among Haemodialysis Patients and Those with Normal Renal Functions', EKB Journal Management System, 89(2), pp. 6889-6894. doi: 10.21608/ejhm.2022.271907
Mahmoud, A., El Ameen, H., Mostafa, N. Comparing The Efficacy and Safety of (Ombitasvir/ Paritaprevir/ Ritonavir) in Management of Chronic HCV Patients Among Haemodialysis Patients and Those with Normal Renal Functions. EKB Journal Management System, 2022; 89(2): 6889-6894. doi: 10.21608/ejhm.2022.271907

Comparing The Efficacy and Safety of (Ombitasvir/ Paritaprevir/ Ritonavir) in Management of Chronic HCV Patients Among Haemodialysis Patients and Those with Normal Renal Functions

The Egyptian Journal of Hospital Medicine
Article 121, Volume 89, Issue 2, October 2022, Page 6889-6894  XML PDF (436.09 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.271907
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Authors
Alaa Ahmed Mahmoud email ; Hussein El Ameen; Nashwa Mostafa
Abstract
Background: In the past, interferon use made it challenging to treat hepatitis C virus (HCV) infection in people with chronic renal disease (IFN). Due to decreased renal clearance of IFN, it was linked to IFN-related adverse events with a significant risk.
Objective: This study aimed to evaluate the antiviral efficacy, safety, and tolerability of ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) in chronic kidney disease patients infected with chronic HCV.
Patients and Methods: This study was conducted on HCV patients who undergo haemodialysis and patients with normal renal functions who had taken OBV/PTV/r. The study was done at the period from May 2017 to May 2018. The study included 47 patients with chronic HCV infection on regular dialysis (study group) and 50 patients with chronic HCV infection (control group).
Results: In our cohort, the mean age of the study group was 43.43 ± 10.56 years while mean age of the control group was 46.80 ± 6.86 years. The majority of the studied groups were males. It was noticed that all enrolled subjects enrolled in the study achieved sustained virological response (SVR) at 12 weeks and 24 weeks. The most frequent adverse effects were fatigue, myalgia and epigastric pain.
Conclusion: Paritaprevir/ritonavir and ombitasvir for 12 weeks were considered to be safe and effective in the treatment of chronic HCV infected patients with end stage renal disease.
 
 
Keywords
End-stage renal disease; Hepatitis C virus; Renal impairment; Sustained virological response
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