Impact of narinigin on induced testicular damage via autophagy and apoptosis pathways modulations in rats
Izzularab, B., Eltahan, G., El-said, H., Beltagy, D., Zahran, R. (2022). Impact of narinigin on induced testicular damage via autophagy and apoptosis pathways modulations in rats. EKB Journal Management System, 45(1), 35-49. doi: 10.21608/djs.2022.173094.1044
Batoul Mohamed Izzularab; Ghada M Eltahan; Hadeer M El-said; Doha M Beltagy; Rasha F Zahran. "Impact of narinigin on induced testicular damage via autophagy and apoptosis pathways modulations in rats". EKB Journal Management System, 45, 1, 2022, 35-49. doi: 10.21608/djs.2022.173094.1044
Izzularab, B., Eltahan, G., El-said, H., Beltagy, D., Zahran, R. (2022). 'Impact of narinigin on induced testicular damage via autophagy and apoptosis pathways modulations in rats', EKB Journal Management System, 45(1), pp. 35-49. doi: 10.21608/djs.2022.173094.1044
Izzularab, B., Eltahan, G., El-said, H., Beltagy, D., Zahran, R. Impact of narinigin on induced testicular damage via autophagy and apoptosis pathways modulations in rats. EKB Journal Management System, 2022; 45(1): 35-49. doi: 10.21608/djs.2022.173094.1044

Impact of narinigin on induced testicular damage via autophagy and apoptosis pathways modulations in rats

Delta Journal of Science
Article 3, Volume 45, Issue 1, September 2022, Page 35-49  XML PDF (1.31 MB)
Document Type: Research and Reference
DOI: 10.21608/djs.2022.173094.1044
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Authors
Batoul Mohamed Izzularab email orcid 1; Ghada M Eltahan2; Hadeer M El-said3; Doha M Beltagy4; Rasha F Zahran2
1Biochemistry Division , Chemistry Department, Faculty of Science, Damanhour University
2Department of Chemistry, Biochemistry Division, Faculty of Science, Damietta University, Egypt
3Department of Zoology, Faculty of Science, Damanhour University, Egypt
4Department of Chemistry, Biochemistry Division, Faculty of Science, Damanhour University, Egypt
Abstract
Acrylamide is toxic compound, which has negative impact on reproductive system. This study aimed to evaluate the ameliorating effect of naringin against testicular damage induced by acrylamide in rats. In this study, 70 adult male rats were divided into 7 groups. G1 in which rats didn’t receive any treatment. G2 in which rats were orally received naringin (80 mg/Kg). G3 included rats were injected with Epifasi (100 UI/Kg). G4 included rats were injected with acrylamide (50 mg/Kg). G5, G6 and G7 included acrylamide injected rats then each rat was received (naringin, Epifasi, naringinin + Epifasi), respectively. Testosterone, estradiol, prolactin, semen analysis, the antioxidant parameter, the apoptosis and autophagy parameter were estimated. The results showed that acrylamide reduced testosterone, sperm count and increased estradiol and prolactin level. Acrylamide disrupted redox hemostasis balance, increased both apoptotic and autophagy marker. Treated rats in G5 and G6 showed significant regression in the measured hormones, the antioxidant parameters, apoptotic and autophagy markers. These results confirmed that combined treatment of naringenin and Epifasi in G7 gave the best recovery of toxic effect of acrylamide on biochemical and histological analysis via hormonal disturbance recovery, reliving the cellular redox homeostasis, promoting the anti-apoptotic factor and inhibition of autophagy pathway.
Keywords
Narinigin; Acrylamide; autophagy; Apoptosis; testicular damage
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