Human Adenoviruses 40/41 and Cytokines Response in Children with Diarrhoea | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 139, Volume 89, Issue 2, October 2022, Page 7025-7030 PDF (649.73 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.272502 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Layla Maki AL-Nasrawy; Sahar Mohammed Jawad; Waleed Dakil AL-Nasrawy | ||||
| Abstract | ||||
| Background: One of the most significant etiologic factors in acute gastroenteritis in children is adenovirus types 40/41. Objective: The aim of this research was to diagnosis of adenovirus type 40/41 in children with diarrhoea in three Cities in Iraq; Babylon, AL-Najaf and Karbala, and evaluation of serum concentration of Interferon gamma (IFN-γ), Interleukin (IL) 6 and 10. Patients and methods: A total of 450 stool samples were collected from children with diarrhoea, age range from 1 to 36 month. Adenovirus 40/41 has been detected in stool using Polymerase Chain Reaction (PCR) method. Serum concentration of IFN-γ, IL-6 and 10 have been measurement using Enzyme-linked Immunosorbent Assay (ELISA) technique. Results: Out of 450 stool samples, there were 150 Children (33.3%) infected with adenovirus 40/41, the highest rate of infection was in the Karbala City with 73 infections (16.2%) followed by Najaf and Babylon were recorded 55 (12.2%) and 22 (4.8%) respectively. Cytokines profile revealed a significantly substantial rise in viral patients compared to controls. IFN-γ, IL-6 and IL-10 levels in the age range of 1 to 36 months were higher than those in the control group at 69.5, 61.3 and 112.3 pg/ml respectively. Conclusions: There were high infections with adenovirus type 40/41 in Karbala City. Interferon-γ, IL-6 and IL-10 play an | ||||
| Keywords | ||||
| Adenovirus; 40/41; PCR; IFN-γ; IL-6; IL-10; case control study; University of Kufa | ||||
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