Effect of Rapid Correction of Serum Cholecalciferol Deficiency on Protection against Clinical Manifest COVID-19 Infection | ||||
| Zagazig University Medical Journal | ||||
| Article 8, Volume 30, Issue 1, January and February 2024, Page 66-73 PDF (953.94 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2022.171129.2668 | ||||
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| Authors | ||||
Ayman Ramadan Abdel-Hai1; Marwa M. Esawy2; Abdalla M. Nawara1; Amir Abdel-Hameed Ahmed   3
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| 1Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 2Clinical Pthology Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3Internal medicine,faculty of medicine,zagazig university,Egypt | ||||
| Abstract | ||||
| Background and Aim: Vitamin D has anti-viral, anti-inflammatory, and metabolic effects. The goal of this study was to evaluate the link between vitamin D level and COVID-19 incidence and to identify the result of short-term vitamin D deficiency correction in prophylaxis of COVID-19 disease. Patients and Methods: A prospective open-label controlled trial was carried out on 897 enrolled subjects who had contact with relatives infected by COVID-19 disease randomized into two arms according to baseline vitamin D level; the first arm of which 816 subjects (90.97% vitamin D deficiency) received 200,000 IU cholecalciferol/vitamin D3 every other day with a total of 3 doses, whereas the second arm, 81 subjects (9.03% normal vitamin D) didn't receive vitamin D supplementation. Serum calcium and serum vitamin D were measured at baseline and 2 weeks after treatment. CBC, ESR, CRP, ferritin, and D-dimer were performed in suspected cases. Results: Symptoms compatible with COVID-19 were 17.3% in the second arm and 16.4% in the first arm, Laboratory-confirmed diagnosis were 3.7% in the second arm and 5.4% in the first arm. Hospitalization was 1.2% in the second arm and 0.4% in the first arm. Deficient vitamin D levels increased the risk of symptoms compatible with COVID-19 disease by 1.66 folds. Conclusions: Rapid correction of vitamin D deficiency protective against COVID-19 infection. | ||||
| Keywords | ||||
| COVID-19; Vitamin D; Inflammatory markers | ||||
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