Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems
Elsherbeeny, W., El-Gogary, R., Nasr, M., Sammour, O. (2022). Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems. EKB Journal Management System, 6(2), 221-238. doi: 10.21608/aps.2022.168128.1101
walaa Elsherbeeny; Riham El-Gogary; Maha Nasr; Omaima Sammour. "Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems". EKB Journal Management System, 6, 2, 2022, 221-238. doi: 10.21608/aps.2022.168128.1101
Elsherbeeny, W., El-Gogary, R., Nasr, M., Sammour, O. (2022). 'Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems', EKB Journal Management System, 6(2), pp. 221-238. doi: 10.21608/aps.2022.168128.1101
Elsherbeeny, W., El-Gogary, R., Nasr, M., Sammour, O. Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems. EKB Journal Management System, 2022; 6(2): 221-238. doi: 10.21608/aps.2022.168128.1101

Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems

Archives of Pharmaceutical Sciences Ain Shams University
Article 5, Volume 6, Issue 2, December 2022, Page 221-238  XML PDF (790.58 K)
Document Type: Review Article
DOI: 10.21608/aps.2022.168128.1101
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Authors
walaa Elsherbeeny email 1; Riham El-Gogary2; Maha Nasr2; Omaima Sammour2
1Central Administration of Operation, Department of Factory Inspection, Egyptian Drug Authority, Cairo, Egypt
2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt
Abstract
ABSTRACT
The oral route of administration is considered the easiest, most convenient and widely used drug delivery route. One of the hardest challenges facing oral drug delivery systems (DDS) is the erratic absorption of drugs through the gastrointestinal tract (GIT). The conventional oral dosage forms usually suffer from low bioavailability especially in case of drugs with narrow absorption window (NAW). The oral controlled release dosage forms could overcome the previous limitation by providing predicted and calculated drug release, resulting in improvement of the efficacy of drugs. One of the most promising types of oral controlled release dosage forms for this purpose is the gastro retentive drug delivery system (GRDDS), which was found to improve the gastric retention of the dosage form and maximize the absorption and bioavailability of the drugs with NAW. In this review, we summarize the different GRDDS techniques used for improving drug absorption, their methods of preparation, and their mechanisms of action.
Keywords
Keywords: Oral route; Controlled release; Narrow absorption window; Gastroretentive delivery systems; Tablets
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