Genetic Polymorphism of Interferon Regulatory Factor 5 Gene in Egyptian Children with Systemic Lupus Erythematosus
El-Nemr, D., Gawish, H., Al Alghobashy, A., Elkafrawy, A., Hassan, A. (2022). Genetic Polymorphism of Interferon Regulatory Factor 5 Gene in Egyptian Children with Systemic Lupus Erythematosus. EKB Journal Management System, 89(2), 7176-7181. doi: 10.21608/ejhm.2022.273061
Dina Mohamed El-Sayed El-Nemr; Heba Hassan Hassan Gawish; Ashgan Abdallah Abdul Al Alghobashy; Amira Eid Ahmed Elkafrawy; Asmaa Ahmed Saad Hassan. "Genetic Polymorphism of Interferon Regulatory Factor 5 Gene in Egyptian Children with Systemic Lupus Erythematosus". EKB Journal Management System, 89, 2, 2022, 7176-7181. doi: 10.21608/ejhm.2022.273061
El-Nemr, D., Gawish, H., Al Alghobashy, A., Elkafrawy, A., Hassan, A. (2022). 'Genetic Polymorphism of Interferon Regulatory Factor 5 Gene in Egyptian Children with Systemic Lupus Erythematosus', EKB Journal Management System, 89(2), pp. 7176-7181. doi: 10.21608/ejhm.2022.273061
El-Nemr, D., Gawish, H., Al Alghobashy, A., Elkafrawy, A., Hassan, A. Genetic Polymorphism of Interferon Regulatory Factor 5 Gene in Egyptian Children with Systemic Lupus Erythematosus. EKB Journal Management System, 2022; 89(2): 7176-7181. doi: 10.21608/ejhm.2022.273061

Genetic Polymorphism of Interferon Regulatory Factor 5 Gene in Egyptian Children with Systemic Lupus Erythematosus

The Egyptian Journal of Hospital Medicine
Article 159, Volume 89, Issue 2, October 2022, Page 7176-7181  XML PDF (579.66 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.273061
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Authors
Dina Mohamed El-Sayed El-Nemr; Heba Hassan Hassan Gawish; Ashgan Abdallah Abdul Al Alghobashy; Amira Eid Ahmed Elkafrawy; Asmaa Ahmed Saad Hassan
Abstract
Introduction: Systemic lupus erythematosus (SLE) is considered an autoimmune disorder that influence many organs, distinguished by complement activation, synthesis of many autoantibodies, organ damage, and deposition of immune complex.
Objective: Examine the relationship between the interferon regulatory factor 5 (IRF5) gene's genetic polymorphism and lupus nephritis disease activity as well as the correlation between SLE and these conditions.
Patients and methods: Sixty-three children were included and classified into three groups as follows: 21 children with lupus nephritis (LN), 21 lupus children without nephritis, and 21 control cases. Blood samples from all children were tested for the IRF5 gene (rs2004640) polymorphism utilizing the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results: Cases and controls differed in high statistically significant way regarding the frequency of TT genotype (64.3% and 23.8% respectively with p value <0.001) and frequency of risk allele T (77.4% and 38.1% respectively with p <0.001). However, when it came to IRF5 genotypes and alleles, there was no statistically significant difference between those with and without nephritis.
Conclusion: Children in Egypt who have the rs2004640 T allele and TT genotype may be at increased risk of developing SLE. Egyptian children with SLE who carry the rs2004640 T allele or TT genotype do not have an increased risk of developing nephritis.
 
Keywords
IRF5; Lupus Erythematosus; Genotype; Polymorphism
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