New Cortisol Schiff Base Synthesis and Some Complexes: Anti-inflammatory studies in silico and in vitro
Soliman, A., Abbas, A., Youssef, M., Gardouh, A., Orabi, A. (2023). New Cortisol Schiff Base Synthesis and Some Complexes: Anti-inflammatory studies in silico and in vitro. EKB Journal Management System, 3(1), 1-11. doi: 10.21608/aels.2022.176601.1024
Amira Salama Soliman; Abbas Mamdouh Abbas; Mohamed Fathy Youssef; Ahmed Rifaat Gardouh; Adel Sayed Orabi. "New Cortisol Schiff Base Synthesis and Some Complexes: Anti-inflammatory studies in silico and in vitro". EKB Journal Management System, 3, 1, 2023, 1-11. doi: 10.21608/aels.2022.176601.1024
Soliman, A., Abbas, A., Youssef, M., Gardouh, A., Orabi, A. (2023). 'New Cortisol Schiff Base Synthesis and Some Complexes: Anti-inflammatory studies in silico and in vitro', EKB Journal Management System, 3(1), pp. 1-11. doi: 10.21608/aels.2022.176601.1024
Soliman, A., Abbas, A., Youssef, M., Gardouh, A., Orabi, A. New Cortisol Schiff Base Synthesis and Some Complexes: Anti-inflammatory studies in silico and in vitro. EKB Journal Management System, 2023; 3(1): 1-11. doi: 10.21608/aels.2022.176601.1024

New Cortisol Schiff Base Synthesis and Some Complexes: Anti-inflammatory studies in silico and in vitro

Advances in Environmental and Life Sciences
Volume 3, Issue 1, January 2023, Page 1-11  XML PDF (673.56 K)
Document Type: Original research articles
DOI: 10.21608/aels.2022.176601.1024
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Authors
Amira Salama Soliman email 1; Abbas Mamdouh Abbas1; Mohamed Fathy Yousseforcid 1; Ahmed Rifaat Gardouh2, 3; Adel Sayed Orabi1
1Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt
2Department of pharmaceutics and industrial pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
3Department of Pharmacy, Faculty of Pharmacy, Jadara University, Irbid 221110, Jordan
Abstract
Schiff base compounds demonstrated exceptional efficiency and activity in the synthesis of several important drugs, including anti-tumor and anti-bacterial agents. Schiff base compounds proved their great efficiency and activity in the synthesis of some important drugs, such as anti-tumor, anti-bacterial, and anti-inflammatory agents. A new Schiff base (HEA) was synthesized from hydrocortisone and ethanol amine. The metal complexes were then formed. The metals selected for the preparation of complexes were derived from copper chloride, nickel chloride, magnesium sulfate, and vanadium sulfate. Fourier transform infrared (FTIR), nuclear magnetic resonance (1HNMR), mass, ultra-visible spectroscopy, and thermal studies were used to characterize the synthesized Schiff base ligand. While FTIR spectra, metal percent, UV-visible spectra, thermal analysis, magnetic measurements, and kinetic measurements were used to characterize the prepared complexes. We evaluated the application of biological docking using COX2 (PDB code: 5IKT (Homo sapiens)). The binding energy of HEA was -14.45 kcal/mol, slightly higher than hydrocortisone. The anti-inflammatory activity of hydrocortisone and HEA was tested in vitro and found to be selective for COX2 with IC50 values of 1.72 and 2.29, respectively.
Keywords
Complexes; Hydrocortisone; Ethanol Amine; Schiff Base; In silico
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