Grape Seed Proanthocyanidin Extract or Spirulina platensis alleviates blood biochemical and hepatic molecular derangements of experimentally-induced thyroid dysfunction in rats
Hussein, S., Abdel Aal, S., Mahfouz, M., Hussein, A. (2022). Grape Seed Proanthocyanidin Extract or Spirulina platensis alleviates blood biochemical and hepatic molecular derangements of experimentally-induced thyroid dysfunction in rats. EKB Journal Management System, 42(2), 25-30. doi: 10.21608/bvmj.2022.148341.1553
Samy Ali Hussein; Samir Abdel Lateif Abdel Aal; Mohammed Mahfouz; Asmaa Hamdi Hussein. "Grape Seed Proanthocyanidin Extract or Spirulina platensis alleviates blood biochemical and hepatic molecular derangements of experimentally-induced thyroid dysfunction in rats". EKB Journal Management System, 42, 2, 2022, 25-30. doi: 10.21608/bvmj.2022.148341.1553
Hussein, S., Abdel Aal, S., Mahfouz, M., Hussein, A. (2022). 'Grape Seed Proanthocyanidin Extract or Spirulina platensis alleviates blood biochemical and hepatic molecular derangements of experimentally-induced thyroid dysfunction in rats', EKB Journal Management System, 42(2), pp. 25-30. doi: 10.21608/bvmj.2022.148341.1553
Hussein, S., Abdel Aal, S., Mahfouz, M., Hussein, A. Grape Seed Proanthocyanidin Extract or Spirulina platensis alleviates blood biochemical and hepatic molecular derangements of experimentally-induced thyroid dysfunction in rats. EKB Journal Management System, 2022; 42(2): 25-30. doi: 10.21608/bvmj.2022.148341.1553

Grape Seed Proanthocyanidin Extract or Spirulina platensis alleviates blood biochemical and hepatic molecular derangements of experimentally-induced thyroid dysfunction in rats

Benha Veterinary Medical Journal
Volume 42, Issue 2, September 2022, Page 25-30  XML PDF (1.13 MB)
Document Type: Original Article
DOI: 10.21608/bvmj.2022.148341.1553
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Authors
Samy Ali Hussein1; Samir Abdel Lateif Abdel Aal2; Mohammed Mahfouz3; Asmaa Hamdi Hussein email 4
1Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt.
2Department of Animal, Poultry and environmental hygiene, Faculty of Veterinary Medicine, Benha University, Egypt
3Biochemistry- veterinary medicine- benha University-Egypt
4Benha veterinary
Abstract
Hyper or Hypothyroidism are an overactive or underactive thyroid gland that prevents the body from operating properly. The potential therapeutic effects of spirulina platensis and GSPE on experimental hypothyroidism and hyperthyroidism in rats were evaluated.A total 96 rats were split into two main experimental groups: Experiment A: carbimazole-induced hypothyroidism(1.8mg/kg b.wt) and experiment B: - induced hyperthyroidism(50, 100, 200ug/kg b.wt) for the first three weeks, respectively.The administered GSPE dose (150/kg b. wt/day) and Spirulina (300mg/kg b. wt/day) for 3 weeks.The Hyperthyroidism experiment (A)six sets of rats were used: Group 1(control normal), Group 2(hyperthyroidism),Group3 (GSPE Protected): GSPE administered for the first 3 weeks and continued with Thyroxine for another 3 week. Group 4 (GSPE treated): Thyroxine administeredfor 3 weeks, followed by GPSE as in group 3. Group 5 (Spirulina Protected); Spirulina and Thyroxine administration as in group 3. Group 6 (Spirulina treated): Spirulina andThyroxineadministration in group IV.The Hypothyroidism experiment (B) rats divided also into 6 groups similar the above design in Hyperthyroidism experiment (A) but carbimazole dose is stable (1.8mg/kg b.wt) in the 3 weeks.In Hyperthyroidism Spirulina and GPSE increase serum total cholesterol, triacylglycerols with down regulation of liver Caspase-8 and significant upregulation of Bcl2 gene. In HypothyroidismSpirulina and GPSE exhibited down regulation in liver miRNA 224, PKCα with significant upregulation of miRNA 382gene in Hypothyroid rats.Spirulina and grape seed may treat and prevent hyperthyroidism or Hypothroidsim in rats, according to a new study.
Keywords
Hyperthyroidism; Hypothyroidism; Proanthocyanidin; spirulina; MicroRNA
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