Rosemary and hesperidin alleviate cardiac dysfunction and alter cellular signaling pathways in experimental model of diabetic cardiomyopathy | ||||
Benha Veterinary Medical Journal | ||||
Volume 42, Issue 2, September 2022, Page 37-42 PDF (1.2 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bvmj.2022.148132.1545 | ||||
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Authors | ||||
Samy Ali Hussein1; omayma ragab Abo zaid2; Hussein Abdelmaksoud3; Taheya Ismael4; Ghada Fathy Al lawaty 3 | ||||
1Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt. | ||||
2Biochemistry veterinary medicine Banha university | ||||
3Biochemistry- veterinary medicine- benha University-Egypt | ||||
4Nutrition &Clinical Nutrition- veterinary medicine- benha University-Egypt | ||||
Abstract | ||||
Alterations in the cardiac structure and function are the hallmarks of diabetic cardiomyopathy (DCM), separate coronary heart disease in diabetic patients. In a streptozotocin-induced diabetic rat model, the current research aimed to investigate the preventive effects of rosemary extract and hesperidin on DCM. Fifty male Rats were divided into five main groups. Group Ι: rats received no drugs. Group Π: STZ (50 mg/kg b. wt.) was given intraperitoneally (i.p.) to rats just once. Group III: Rats treated with insulin at a dose of (2 U/rat/day). Group IV: rats treated with Rosemary extract at a dose of (200 mg/kg b. wt /day). Group V: rats treated with Hesperidin at a dose of (100 mg/kg b. wt/day). The results showed a marked increase in serum total cholesterol and triacylglycerol concentrations and downregulation in Peroxisome proliferator-activated receptor-γ (PPAR-γ) and Sarcoplasmic reticulum Ca2+-ATPase (SERCA) genes expressions with upregulation in Collagen type IV (COL4) in cardiac tissue of DCM-induced group. Treatment with insulin, rosemary extract, or hesperidin to STZ-induced DCM in rats exhibited a substantial reduction in the levels of triacylglycerol and total cholesterol with an enormous downregulation of COL4 gene expression level in cardiac tissue. However, PPAR-γ and SERCA genes exhibited an enormous upregulation. In conclusion, the results indicated that rosemary extract and hesperidin have a beneficial effect in preventing lipid metabolic disorders and diabetes complications and modify several genes such as PPAR-γ, SERCA, and COL4 participating in cellular pathways which altered in DCM. | ||||
Keywords | ||||
Diabetic cardiomyopathy; rosemary extract; hesperidin; SERCA and PPAR-γ | ||||
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