The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats
taima, S., Elsayed, F., Emam, M., Ibrahim, S., Aboubakr, M. (2022). The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats. EKB Journal Management System, 42(2), 109-113. doi: 10.21608/bvmj.2022.146800.1537
Shimaa taima; Faten Elsayed; Mahmoud Abdelghaffar Emam; samar saber Ibrahim; Mohamed Aboubakr. "The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats". EKB Journal Management System, 42, 2, 2022, 109-113. doi: 10.21608/bvmj.2022.146800.1537
taima, S., Elsayed, F., Emam, M., Ibrahim, S., Aboubakr, M. (2022). 'The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats', EKB Journal Management System, 42(2), pp. 109-113. doi: 10.21608/bvmj.2022.146800.1537
taima, S., Elsayed, F., Emam, M., Ibrahim, S., Aboubakr, M. The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats. EKB Journal Management System, 2022; 42(2): 109-113. doi: 10.21608/bvmj.2022.146800.1537

The combined protective effect of N-acetylcysteine and vitamin E against acrylamide-induced nephrotoxicity in rats

Benha Veterinary Medical Journal
Volume 42, Issue 2, September 2022, Page 109-113  XML PDF (1.05 MB)
Document Type: Original Article
DOI: 10.21608/bvmj.2022.146800.1537
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Authors
Shimaa taima1; Faten Elsayed1; Mahmoud Abdelghaffar Emam2; samar saber Ibrahimorcid 3; Mohamed Aboubakr email 4
1Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt.
2Histology Dept., Faculty of Veterinary Medicine, Benha University
3forensic medicine and toxicology, faculaty of veterinary medicine , benha university
4Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt
Abstract
The purpose of this study was to see if N-acetylcysteine (NAC) and/or Vitamin E (Vit E) could help rats with renal damage caused by acrylamide (ACR). The antioxidant and nephroprotective efficacy of NAC and Vit E against ACR-induced nephrotoxicity in rats was investigated in this workThe rats were assigned to seven groups (each with seven rats): control vehicle group (saline only), NAC group (150 mg/kg, orally), Vit E group (100 mg/kg, orally), ACR group (20 mg/kg, orally), NAC+ACR group, Vit E+ACR group, and NAC+Vit E+ACR group. Creatinine, urea, and glucose concentrations in the blood rose as a result of ACR. Furthermore, ACR reduced protein and albumin levels. Malondialdehyde levels in kidney tissues increased dramatically as reduced glutathione, superoxide dismutase, and catalase levels decreased. ACR also caused certain degenerative lesions in the kidney tissues and elevated caspase-3 expression. NAC and Vit E, either alone or in combination reduced kidney toxicity and apoptosis caused by ACR.
Keywords
N-acetylcysteine; Caspase-3; Acrylamide; Renal Toxicity; Vitamin E
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