A Comparative Study on the Effect of Two Topical Formulations of Bee Propolis Cream in Ordinary and Nano Form on Wound Healing in Aged Rats (A Histological and Immunohistochemical Study) | ||||
| Egyptian Journal of Histology | ||||
| Articles in Press, Accepted Manuscript, Available Online from 10 December 2022 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2022.154572.1747 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Noha Ibrahim  1; Aliaa Hassan2; Waleed ragab3; Enas Morsi4; Asmaa Elsayed5
| ||||
| 158 مکرر مريوطيه فيصل امام کوبرى الشيشينى الدور ١٢ | ||||
| 22. Biochemistry Department, National Organization for Drug Control & Research, Giza, Egypt | ||||
| 33. Anatomy and Embryology Department, Faculty of Medicine, Fayoum University, Egypt | ||||
| 45. Forensic and Toxicology Department, Faculty of Medicine, Fayoum University, Egypt | ||||
| 51. Histology and cell Biology Department, Faculty of Medicine, Fayoum University, Egypt | ||||
| Abstract | ||||
| Background: Aging could result in delayed wound healing. propolis has good effect on healing. Objectives: This investigation was done to assess whether propolis and nanopropolis creams could aid in the healing of wounds in aged rats. Materials and methods: Fifty old-aged albino rats have been separated into four groups: group I (control intact skin) (5 rats); wounded groups: group II (control wounded) (3 subgroups, 5 rats each); subgroup IIa: had vehicle cream once per day for 7 days; subgroup IIb: had vehicle cream once per day for 14 days; and subgroup IIc: had vehicle cream once per day for 21 days; group III (propolis group), which has been divided into 3 subgroups with 5 rats each, received propolis cream once per day for 7 days (subgroup IIIa); once per day for 14 days (subgroup IIIb); and once per day for 21 days (subgroup IIIc), group IV (nanopropolis group), which has been divided into 3 subgroups with 5 rats each, and treatment were topically applied for the same durations as the aforementioned in group III. Hematoxylin and eosin stain, picro sirius red histochemical reaction, and CD 105 immunostain were used in this study. Results: Wound healing was significantly improved in the propolis and nanopropolis groups, with a significant increase in the rate of wound closure and collagen deposition. Conclusion: the current study results confirmed the importance of CD105 in the process of wound healing. Additionally, it demonstrated how effectively propolis and nanopropolis formulas treated aged wounds. This technique might be effective for treating chronic wounds safely and efficiently. | ||||
| Keywords | ||||
| propolis; nanopropolis; aged; wound healing; CD 105 | ||||
|
Statistics Article View: 240 |
||||
