Potential Anti-fungal Activity of Lactobacilli Probiotic Against Fluconazole Resistant Candida albicans Clinical Isolates
El-Ashmony, M., Raslan, F., Abdelhamid, D., Hafez, H., Abd El-Rahman, O. (2023). Potential Anti-fungal Activity of Lactobacilli Probiotic Against Fluconazole Resistant Candida albicans Clinical Isolates. EKB Journal Management System, 3(1), 120-131. doi: 10.21608/aijpms.2022.131769.1123
Mai M El-Ashmony; Fatma S Raslan; Dalia H Abdelhamid; Hala M Hafez; Ola A Abd El-Rahman. "Potential Anti-fungal Activity of Lactobacilli Probiotic Against Fluconazole Resistant Candida albicans Clinical Isolates". EKB Journal Management System, 3, 1, 2023, 120-131. doi: 10.21608/aijpms.2022.131769.1123
El-Ashmony, M., Raslan, F., Abdelhamid, D., Hafez, H., Abd El-Rahman, O. (2023). 'Potential Anti-fungal Activity of Lactobacilli Probiotic Against Fluconazole Resistant Candida albicans Clinical Isolates', EKB Journal Management System, 3(1), pp. 120-131. doi: 10.21608/aijpms.2022.131769.1123
El-Ashmony, M., Raslan, F., Abdelhamid, D., Hafez, H., Abd El-Rahman, O. Potential Anti-fungal Activity of Lactobacilli Probiotic Against Fluconazole Resistant Candida albicans Clinical Isolates. EKB Journal Management System, 2023; 3(1): 120-131. doi: 10.21608/aijpms.2022.131769.1123

Potential Anti-fungal Activity of Lactobacilli Probiotic Against Fluconazole Resistant Candida albicans Clinical Isolates

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 12, Volume 3, Issue 1, January 2023, Page 120-131  XML PDF (527.95 K)
Document Type: Original research articles
DOI: 10.21608/aijpms.2022.131769.1123
View on SCiNiTO View on SCiNiTO
Authors
Mai M El-Ashmony email orcid 1; Fatma S Raslan1; Dalia H Abdelhamid2; Hala M Hafez2; Ola A Abd El-Rahman1
1Department pf Microbiology and Immunology, Faculty of pharmacy (Girls), Alazhar university, Cairo, Egypt.
2Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Abstract
Fluconazole resistance of Candida albicans (C. albicans) is a growing medical issue which makes patient management more difficult. The development of new effective, safe and inexpensive alternatives becomes essential. Probiotics represent an intriguing strategy that can be used for prevention or treatment of Candida infections. The aim of our study is to investigate the anti-fungal activity of various Lactobacillus species against fluconazole resistant C. albicans isolates and to assess the inhibitory effect of cell free supernatant of most potent one. Sixty-nine C. albicans isolates were obtained from different clinical specimens and subjected to antifungal susceptibility testing. Then, the anti-Candida activity of various Lactobacillus spp was investigated via different methods. Results showed that 33% of C. albicans isolates were fluconazole resistant with MIC ≥ 64 μg/ml. L. rhamnosus demonstrated strong inhibition activity against majority of fluconazole resistant C. albicans isolates, followed by L. reuteri and L. salivarus respectively. Inhibitory activity of L. rhamnosus against C. albicans may be due to acid production. Our findings conclude that L. rhamnosus represent a promising candidate to be used in the treatment of candidiasis caused by fluconazole-resistant C. albicans strains.
Keywords
Fluconazole resistance; Candida albicans; Lactobacillus rhamnosus; Lactobacillus reuteri; Lactobacillus salivarus
Supplementary Files
Statistics
Article View: 318
PDF Download: 446