Circular Ribonucleic Acid Expression in Patient with Acne
El-Taweel, A., Al-Refae, A., Abd-Ellateef, M., Mohammad, R. (2022). Circular Ribonucleic Acid Expression in Patient with Acne. EKB Journal Management System, 3(4), 209-227. doi: 10.21608/ejmr.2021.88645.1101
Abd-Elaziz Ibrahim El-Taweel; Abd-Elaziz Abdul-salam Al-Refae; Mona ELsayed Ahmed Abd-Ellateef; Randa Nady Mohammad. "Circular Ribonucleic Acid Expression in Patient with Acne". EKB Journal Management System, 3, 4, 2022, 209-227. doi: 10.21608/ejmr.2021.88645.1101
El-Taweel, A., Al-Refae, A., Abd-Ellateef, M., Mohammad, R. (2022). 'Circular Ribonucleic Acid Expression in Patient with Acne', EKB Journal Management System, 3(4), pp. 209-227. doi: 10.21608/ejmr.2021.88645.1101
El-Taweel, A., Al-Refae, A., Abd-Ellateef, M., Mohammad, R. Circular Ribonucleic Acid Expression in Patient with Acne. EKB Journal Management System, 2022; 3(4): 209-227. doi: 10.21608/ejmr.2021.88645.1101

Circular Ribonucleic Acid Expression in Patient with Acne

Egyptian Journal of Medical Research
Volume 3, Issue 4, October 2022, Page 209-227  XML PDF (705.42 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2021.88645.1101
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Authors
Abd-Elaziz Ibrahim El-Taweel1; Abd-Elaziz Abdul-salam Al-Refae2; Mona ELsayed Ahmed Abd-Ellateef2; Randa Nady Mohammad email 3
1Dermatology and Andrology Department, Faculty of Medicine, benha university
2Dermatology and Andrology Department, Faculty of Medicine, beni-suef university
3Dermatology. Faculty of benj souif
Abstract
Background: Acne is a common chronic skin disease with a multifactorial aetiology and pathogenesis. Recently, circular RNAs (circRNAs) have been identified as a key factor in regulating gene expression through circRNA–miRNA–mRNA networks in many biological processes and human diseases. However, the circRNAs expression in patients with acne is still unknown, Aim and Objectives: To evaluate circular RNA Expression in Patient with Acne and to correlate its level with acne severity, Subjects and Methods: this was a case control study was conducted at conducted at Dermatology outpatient clinic at Beni-Suef University hospital including 40 with acne vulgaris and 40 normal as control. The duration of the study ranged from 6 months, Results: The mean CIRCULAR RNA 0001073 for cases group was 0.47 (±0.3 SD) with range (0.11-1.2) and that the mean CIRCULAR RNA 0001073 for control group was 1.03 (±0.1 SD) with range (0.95-1.2), and There was high statistically significant difference between the studied groups as regard CIRCULAR RNA 0001073. Conclusion: This study firstly showed that circRNAs were differentially expressed in severe acne and suggested that circRNAs could be used as a potential biomarker for the drug targets of acne.
Keywords
CircRNA; Skin Diseases; Acne; Expression; Biomarker; Severity
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