ASSOCIATION OF LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5 4037C>T VARIANT WITH NEPHROPATHY IN ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS | ||||
| Al-Azhar Journal of Pediatrics | ||||
| Article 9, Volume 25, Issue 4, October 2022, Page 3078-3093 PDF (878.49 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/azjp.2022.274058 | ||||
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| Abstract | ||||
| Background: In people who have uncontrolled T1DM, microvascular problems such diabetic nephropathy (DN) occur. The co-receptor ligands of the Wnt signalling pathway is lower density lipoprotein receptors-related protein 5 (LRP5). The human LRP5 genes have several single nucleotide variations that have been linked to metabolic diseases. It has been suggested that the Wnt/-catenin pathway is crucial in a number of metabolic diseases, particularly diabetic nephropathy. Unfortunately, there are few research investigating the function of the LRP5 genes variation in T1DM. Purpose: The progression of diabetes sequelae, including diabetic nephropathy and dyslipidemia, in addition to the relationship between the LRP5 variation 4037C>T and indicators of glycemic and metabolic control were examined in this cross-sectional case-control research of adolescents with T1DM. Methods: Twenty age- and sex-matched control subjects and 40 juvenile T1DM participants participated in this study. All trial subjects underwent thorough history-taking, clinical evaluations, and lab tests to determine their glucose control and risk of diabetic microvascular complications. Employing real-time PCR, the LRP5 gene (rs3736228) variation assay was carried out. Results: The current investigation found no statistically significant change in the LRP5 rs3736228 gene variant between identical control subjects and adolescents with T1DM. A lack of a statistically relevant correlation between the LRP5 gene variation and the onset of diabetic nephropathy was found. Furthermore, there was a statistically significant correlation between obesity and hypercholesterolemia in T1DM individuals with the CT genotypes. Teenagers with DN had HbA1c levels that were considerably greater than those without DN (p=0.018). Conclusion: According to the research, there is no connection between the LRP5 4037C>T variation and diabetic nephropathy in hospitalized children. Furthermore, there is a statistically significant correlation between the genotype CT and elevated BMI and hypercholesterolemia. Additional research is required to examine numerous gene variations associated with glycemic management and the emergence of diabetic complications. | ||||
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