T helper 17 cells and interleukin-17 contribute to the pathogenesis of primary immune thrombocytopenia in Egyptian children: a single center experience.

Hassan, Tamer; Abdel-Fattah, Nermin Raafat; Esh, Asmaa; Abu Hashim, Mustafa Ismail

doi:10.21608/zumj.2022.180391.2700

	T helper 17 cells and interleukin-17 contribute to the pathogenesis of primary immune thrombocytopenia in Egyptian children: a single center experience.
Zagazig University Medical Journal
Article 18, Volume 29, Issue 1, January 2023, Page 149-154 PDF (455.87 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.180391.2700
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Authors
Tamer Hassan¹; Nermin Raafat Abdel-Fattah²; Asmaa Esh³; Mustafa Ismail Abu Hashim ⁴
¹pediatric department , faculty of medicine , zagazig university
²Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt
³Clinical pathology department,faculty of medicine,Zagazig university,Zagazig,Eygpt
⁴Pediatric department, faculty of medicine, Zagazig university
Abstract
background Although the exact pathogenesis of primary immune thrombocytopenia (ITP) is still unclear, there are many research efforts directed toward the role of T helper 17 and interleukin 17 (IL -17) in the pathogenesis of this disease. The Th17 cell, which produces IL -17, is a subset of T helper cells. Interleukin 17 is a proinflammatory cytokine that has recently been shown to play a critical role in the development of autoimmune diseases. Our aim was to investigate the role of T helper cells 17 and interleukin-17 in the development of ITP in Egyptian children. Methods and results This study was performed on 100 children with ITP and 100 healthy children as a control group. Patients underwent a complete history, a thorough physical examination, and routine investigations according to our local standards. The percentage of Th17 cells was measured in the study groups by flow cytometry. Serum IL -17 was also measured by ELISA in the study groups. Th17 cells were significantly higher in patients compared with controls. In addition, serum levels of IL -17 were observed to be 3.1-fold higher in patients with ITP compared to controls. Newly diagnosed patients had a significantly higher percentage of Th-17 cells as well as higher IL -17 levels than patients with persistent or chronic ITP. conclusion We concluded that Th-17 cells and IL -17 contribute to the pathogenesis of ITP in Egyptian children.
Keywords
ITP: T helper 17; IL-17; Children; Pathogenesis


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