Assessment Of Serum Level Of Selenium And Manganese In B-Thalassemia Major Patients In Beni-Suef University Hospital
Meabed, M., Shafey, E. (2022). Assessment Of Serum Level Of Selenium And Manganese In B-Thalassemia Major Patients In Beni-Suef University Hospital. EKB Journal Management System, 3(4), 242-253. doi: 10.21608/ejmr.2021.91689.1118
Mohamed Hussein Meabed; Esraa Abdelal Shafey. "Assessment Of Serum Level Of Selenium And Manganese In B-Thalassemia Major Patients In Beni-Suef University Hospital". EKB Journal Management System, 3, 4, 2022, 242-253. doi: 10.21608/ejmr.2021.91689.1118
Meabed, M., Shafey, E. (2022). 'Assessment Of Serum Level Of Selenium And Manganese In B-Thalassemia Major Patients In Beni-Suef University Hospital', EKB Journal Management System, 3(4), pp. 242-253. doi: 10.21608/ejmr.2021.91689.1118
Meabed, M., Shafey, E. Assessment Of Serum Level Of Selenium And Manganese In B-Thalassemia Major Patients In Beni-Suef University Hospital. EKB Journal Management System, 2022; 3(4): 242-253. doi: 10.21608/ejmr.2021.91689.1118

Assessment Of Serum Level Of Selenium And Manganese In B-Thalassemia Major Patients In Beni-Suef University Hospital

Egyptian Journal of Medical Research
Volume 3, Issue 4, October 2022, Page 242-253  XML PDF (488.84 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2021.91689.1118
View on SCiNiTO View on SCiNiTO
Authors
Mohamed Hussein Meabedorcid 1; Esraa Abdelal Shafey email 2
1Professor of Pediatrics, Faculty of Medicin, Benisuief University
2Pediatric Department Faculty of Medicine Beni Suef University
Abstract
β- thalassemia major (β-TM) is one of the most common inherited single gene disorder .Children with Thalassemia frequently have poor growth and delayed pubertal development. Selenium and manganese are factors responsible for growth and puberty disorders in thalassemic patients.
Assessment of serum levels of selenium and manganese in patients with β thalassemia major in Pediatric Haematology Clinic in Beni Suef University Hospital. Blood was taken from 50 pediatric patients with b thalassemia major, and 50 normal children as controls . All children were age and sex matched . all children were subjected to full history taking and full clinical examination and investigation was done in the form of CBC, serum Ferritin , serum Selenium and Manganese were measured using spectrophotometer.
Patients with β- thalassemia major have high serum manganese level as compared to normal controls with P value of (0.000), while serum selenium level is insignificant as compared to normal controls with P value of (0.119)
Keywords
Thalassemia; Selenium; Manganese
References
  1. Muncie Jr, H. L., & Campbell, J. S. (2009). Alpha and beta thalassemia. American family physician, 80(4), 339-344.
  2. Tari, K., Valizadeh Ardalan, P., Abbaszadehdibavar, M., Atashi, A., Jalili, A., & Gheidishahran, M. (2018). Thalassemia an update: molecular basis, clinical features and treatment. International journal of biomedicine and public health, 1(1), 48-58
  3. El Missiry, M., Hamed Hussein, M., Khalid, S., Yaqub, N., Khan, S., Itrat, F., ... & Faulkner, L. (2014). Assessment of serum zinc levels of patients with thalassemia compared to their siblings. Anemia, 2014.
  4. Shazia, Q., Mohammad, Z. H., Rahman, T., & Shekhar, H. U. (2012). Correlation of oxidative stress with serum trace element levels and antioxidant enzyme status in Beta thalassemia major patients: a review of the literature. Anemia, 2012.
  5. Akbaraly, T. N., Hininger-Favier, I., Carriere, I., Arnaud, J., Gourlet, V., Roussel, A. M., & Berr, C. (2007). Plasma selenium over time and cognitive decline in the elderly. Epidemiology, 52-58
  6. Martinez-Finley EJ, Gavin CE, Aschner M, Gunter TE (2013): Manganese neurotoxicity and the role of reactive oxygen species.Free Radic Biol Med 62:65–75
  7. Model, B., & Berdoukas, V. (1984). The clinical approach to thalassemia. London: Grune & Stratton, 140-150.
  8. Hambidge, M. (2003). Biomarkers of trace mineral intake and status. The Journal of nutrition, 133(3), 948S-955S.
  9. Sherief, L. M., El-Salam, A., Sanaa, M., Kamal, N. M., Almalky, M. A., Azab, S. F., ... & Gharieb, A. F. (2014). Nutritional biomarkers in children and adolescents with beta-thalassemia-major: an Egyptian center experience. BioMed research international. Article ID 261761, 7 pages.
  10. Helen Bornaun, Dedeoglu, R., Oztarhan, K., Dedeoglu, S., Erfidan, E., Gundogdu, M., ... & Cengiz, D. (2016). Detection of early right ventricular dysfunction in young patients with thalassemia major using tissue Doppler imaging. Iranian journal of pediatrics, 26(3).
  11. Ammar, S. A., Elsayh, K. I., Zahran, A. M., & Embaby, M. (2014). Splenectomy for patients with β-thalassemia major: long-term outcomes. The Egyptian Journal of Surgery, 33(4), 232.
  12. Sachdev, S. (2000). Quantum criticality: competing ground states in low dimensions. Science, 288(5465), 475-480.
  13. El Beshlawy, A., El Tagui, M., Hamdy, M., El Ghamrawy, M., Azim, K. A., Salem, D., ... & Pennell, D. J. (2014). Low prevalence of cardiac siderosis in heavily iron loaded Egyptian thalassemia major patients. Annals of hematology, 93(3), 375-379.
  14. Mohkam, M., Shamsian, B. S., Gharib, A., Nariman, S., & Arzanian, M. T. (2008). Early markers of renal dysfunction in patients with beta-thalassemia major. Pediatric nephrology, 23(6), 971-976.
  15. Alter B. Nathan D, Orkin S, Ginsburg D and Look T. (2002): The hemoglobinopathies in hematology of infancy and childhood , 6th edition, Philadelphia Health Sciences, 385-389.
  16. Genc, G. E., Ozturk, Z., Gumuslu, S., & Kupesiz, A. (2016). Mineral levels in thalassaemia major patients using different iron chelators. Biological trace element research, 170(1), 9-16. 
 

Statistics
Article View: 143
PDF Download: 94