Omentin-1 a Novel Approach Ameliorates Glycemic State, Inflammation and Osteopontin Level in GDM Rat Model: PI3K/AKT/GSK-3 pathway
Fathy, M., Elwany, N., Habib, M., Mohamed, N., Khalil, S. (2023). Omentin-1 a Novel Approach Ameliorates Glycemic State, Inflammation and Osteopontin Level in GDM Rat Model: PI3K/AKT/GSK-3 pathway. EKB Journal Management System, 29(1.1), 248-256. doi: 10.21608/zumj.2022.176472.2689
Maha Abdelhamid Fathy; Nisreen Elnagy Elwany; Marwa Abdelaziz Habib; Noura Mostafa Mohamed; Sama Salah Khalil. "Omentin-1 a Novel Approach Ameliorates Glycemic State, Inflammation and Osteopontin Level in GDM Rat Model: PI3K/AKT/GSK-3 pathway". EKB Journal Management System, 29, 1.1, 2023, 248-256. doi: 10.21608/zumj.2022.176472.2689
Fathy, M., Elwany, N., Habib, M., Mohamed, N., Khalil, S. (2023). 'Omentin-1 a Novel Approach Ameliorates Glycemic State, Inflammation and Osteopontin Level in GDM Rat Model: PI3K/AKT/GSK-3 pathway', EKB Journal Management System, 29(1.1), pp. 248-256. doi: 10.21608/zumj.2022.176472.2689
Fathy, M., Elwany, N., Habib, M., Mohamed, N., Khalil, S. Omentin-1 a Novel Approach Ameliorates Glycemic State, Inflammation and Osteopontin Level in GDM Rat Model: PI3K/AKT/GSK-3 pathway. EKB Journal Management System, 2023; 29(1.1): 248-256. doi: 10.21608/zumj.2022.176472.2689

Omentin-1 a Novel Approach Ameliorates Glycemic State, Inflammation and Osteopontin Level in GDM Rat Model: PI3K/AKT/GSK-3 pathway

Zagazig University Medical Journal
Article 35, Volume 29, Issue 1.1, January 2023, Page 248-256  XML PDF (409.58 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.176472.2689
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Authors
Maha Abdelhamid Fathy email orcid 1; Nisreen Elnagy Elwanyorcid 2; Marwa Abdelaziz Habiborcid 3; Noura Mostafa Mohamed4; Sama Salah Khalilorcid 5
1Medical physiology department-Faculty of medicine-Zagazig university
2Clinical Pharmacology department, zagazig University, faculty of medicine
3Medical Physiology Department, Faculty of Medicine, Zagazig University
4Medical biochemistry department-Faculty of medicine-Zagazig university
5Medical physiology, Zagazig University, Egypt, ElSharquia, Zagazig.
Abstract
Background: Omentin-1 an adipokine expressed in visceral fat, endothelium and gut. Its level was found lower in obesity and type II diabetes. It is expressed in placenta and was associated with insulin sensitivity during pregnancy. Materials & Methods: rats were divided into 4 groups; group I: control, group II: sham group (normal pregnant), group III: gestational diabetic group and group IV: omentin-1 treated gestational diabetic group. Blood glucose, insulin HOMA-IR, lipid profile, CRP and osteopontin (OPN) levels were measured and gene expression of PI3K, AKT, GSK-3, NF-κB and OPN Results: in group III, a significant increase in insulin resistance, CRP, OPN, increased mRNA expression of GSK-3, NF-κB, and OPN while PI3K and AKT expression decreased. Omentin-1 treatment in group IV attenuated insulin resistance, increased PI3K and AKT expression but decreased OPN, GSK-3, and NF-κB expression. Conclusion: Omentin-1 administration in gestational diabetic rats improved insulin sensitivity and attenuated inflammatory response through PI3K/AKT/GSK-3 pathway.
Keywords
Keywords: omentin-1; osteopontin; gestational diabetes; PI3K
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