Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives
G. Sanad, D., S.A. Youssef, A., A. El-Mariaha, F., E. Hashem, H. (2022). Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives. EKB Journal Management System, 39(1), 83-103. doi: 10.21608/jsrs.2022.275777
Dina G. Sanad; Ahmed S.A. Youssef; Fatma A. El-Mariaha; Heba E. Hashem. "Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives". EKB Journal Management System, 39, 1, 2022, 83-103. doi: 10.21608/jsrs.2022.275777
G. Sanad, D., S.A. Youssef, A., A. El-Mariaha, F., E. Hashem, H. (2022). 'Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives', EKB Journal Management System, 39(1), pp. 83-103. doi: 10.21608/jsrs.2022.275777
G. Sanad, D., S.A. Youssef, A., A. El-Mariaha, F., E. Hashem, H. Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives. EKB Journal Management System, 2022; 39(1): 83-103. doi: 10.21608/jsrs.2022.275777

Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives

Journal of Scientific Research in Science
Volume 39, Issue 1, December 2022, Page 83-103  XML PDF (1.82 MB)
Document Type: Original Article
DOI: 10.21608/jsrs.2022.275777
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Authors
Dina G. Sanad* 1; Ahmed S.A. Youssef2; Fatma A. El-Mariaha3; Heba E. Hashem3
1Chemistry Department, Faculty iof Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.
2Chemistry Department, Faculty of Science, Ain Shams University, Abasia, Cairo 11566, Egypt.
3Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.
Abstract
Reactions of 4H-3,1-benzoxazin-4-one 3 with various nitrogen nucleophiles; sodium azide, hydroxylamine hydrochloride, ammonium acetate, and formamide afforded new N-heterocyclic compounds 4-7. The synthesized quinazolinone derivative 7 was used as a useful building block for further synthesis of new series of N3-functionalized quinazolinone compounds 8-12. The chemical structures of all synthesized heterocyclic compounds were deduced from their spectroscopic analyses. The antimicrobial activity of the new compounds was evaluated against several pathogenic microorganisms, and most of them showed remarkable activity comparable to the antibacterial Ciprofloxacin and antifungal Clotrimazole.
Keywords
Benzoxazinone; Quinazolinone; Benzimidazole; Tetrazole; Antimicrobial activity
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