New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation | ||||
Egyptian Journal of Chemistry | ||||
Article 41, Volume 66, Issue 6, June 2023, Page 411-418 PDF (652.32 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2022.178935.7271 | ||||
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Authors | ||||
Mahmoud Ibrahim Nassar ![]() ![]() ![]() ![]() ![]() | ||||
1Natural product chemistry, pharmaceutical institute, NRC. | ||||
2Natural Compounds Chemistry Department, National Research Centre, Dokki, Giza, Egypt | ||||
3Chemistry of Tannins Department, National Research Centre | ||||
4Pharmacognosy Department, Faculty of Pharmacy, Cairo University | ||||
5Pharmacology Department, National Research Centre | ||||
6Natural Compounds Chemistry, National Research Centre | ||||
Abstract | ||||
The phytochemical investigation of the leaves of Cassia notabilis Randell. revealed the isolation of two new glycosides, identified as 6-methoxyapigenin-4`-methyl ether 7- O-α-L-rhamnopyranoside-8-C-β-D-glucopyranoside (1) and 1,7,8-trihydroxyanthraquinone 3-O-β -D-glucopyranoside (7), along with apigenin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (2), acacetin 7- O-α-L-rhamnopyranoside (3), luteolin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (4), luteolin 7-O- β-D-glucpyranoside (5), diosmetin 7- O-α-L-rhamnopyranoside (6). The structures of the isolated compounds were established by chromatographic and spectroscopic evidences. Pharmacological studies showed that the three doses of 70% aqueous methanolic extract of C. notabilis leaves (125, 250 and 500 mg/kg) have antidiabetic, analgesic, anti-inflammatory and antioxidant activity. | ||||
Keywords | ||||
Cassia notabilis; flavonoids; antidiabetic; anti-inflammatory; analgesic; antioxidant | ||||
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