Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder | ||||
Benha Medical Journal | ||||
Article 9, Volume 40, Issue 1, May and June 2023, Page 97-109 PDF (804.15 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bmfj.2022.177773.1721 | ||||
View on SCiNiTO | ||||
Authors | ||||
Enas S. Ahmed1; Neveen A. Abdulhafeez 2; AYA ABDELAZIZ 3; SHABIEB A ABDELBAKY4; ASMAA A. EL-FALLAH 5 | ||||
1Department of Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt | ||||
2Clinical Pathology Department-Faculty Of Medicine-Benha University | ||||
3Clinical & Chemical Pathology department, Faculty of Medicine, Benha University, Egypt | ||||
4Urology department, Faculty of Medicine, Benha University, Egypt | ||||
5assisat professor of Clinical and Chemical Pathology. Faculty of Medicine -Benha University | ||||
Abstract | ||||
Background: Bladder cancer is a very common malignancy worldwide its exact cause is not known, but it is believed to be multifactorial mostly caused by genetic mutations of tumor suppressor gene, proto-oncogenes and DNA repair genes including XRCC3 Thr241Met gene polymorphism. Aim of the study: Identify the link between XRCC3 (rs861539) gene polymorphism and the susceptibility to develop urothelial carcinoma of the bladder (UCB) in the Egyptian patients. Subjects and method: The presence of XRCC3 Thr241Met gene polymorphism (rs 861539) was identified by PCR-RFLP method in 50 patients with urothelial carcinoma of bladder and 50 healthy controls. Results: XRCC3 Thr 241 Met gene polymorphism CC genotype and C allele demonstrated a substantially increased susceptibility in the UCB group than the control group for the risk to develop UCB (OR 3.69, 95% CL 1.52-8.97) (P =0.003), however, while TT genotype and T allele demonstrated a substantially decreased susceptibility in the UCB group than the control group with a protective effect against UCB development (OR 0.096, 95%CL0.035-0.263) (P | ||||
Keywords | ||||
XRCC3; Gene polymorphism; Urothelial carcinoma of the bladder; Genotype; Allele | ||||
Statistics Article View: 124 PDF Download: 218 |
||||