Pyrimidine hydrazide ligand and its metal complexes: synthesis, characterization, and antimicrobial activities | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 5, May 2023, Page 315-329 PDF (2 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.173181.7161 | ||||
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| Authors | ||||
S. El-Sayed Saeed   1; Budoor A. Alomari1; Ahmed N. Alhakimi 1, 2; M. M. Abd El-Hady 1, 3; Jawza Sh Alnawmasi1; Hussein H. Elganzory 1; Wael A. El-Sayed1, 4
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| 1Department of Chemistry, College of Science, Qassim University, Saudi Arabia. | ||||
| 2Department of Chemistry, College of Science, Ibb University, Ibb, Yemen | ||||
| 3National Research Centre (Scopus affiliation ID: 60014618), Institute of Textile Research and Technology, Dokki, Giza 12622, Egypt. | ||||
| 4Photochemistry Department, National Research Centre, Dokki, Giza 12622, Egypt. | ||||
| Abstract | ||||
| Increasing the resistance to current antimicrobial agents has posed a pressing need for the development of new antimicrobial agents. We, therefore, benefit from the antimicrobial characteristics of pyrimidine derivatives to prepare a new 4-(4-bromophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide ligand. The ligand complexes of (3d; Cr, Mn, Fe, Co, Ni, Cu, and Zn) and 4d -Cd metals are also prepared and characterized by different techniques. The ligand acts as a neutral bidentate and exhibited octahedral geometry. In vitro antibacterial activity of the ligand and its complexes against Staphylococcus aureus and Escherichia coli was investigated. Also, the antifungal against Candida albicans and Aspergillus flavus was evaluated. The results showed that the produced complexes have antibacterial activity higher than the ligand. The Cd(II) complex showed antifungal activity higher than the other complexes. | ||||
| Keywords | ||||
| pyrimidine; hydrazide; metal complexes; antimicrobial. | ||||
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