Biological Study of Some Gelditsia Species. | ||||
| Azhar International Journal of Pharmaceutical and Medical Sciences | ||||
| Article 5, Volume 3, Issue 1, January 2023, Page 58-63 PDF (272.12 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/aijpms.2022.143632.1148 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mona M. Eid   1; Marwa S Abu-Bakr 1; Mohamed F. abd-Elwahab 2; Ehab A. Ragab 2
| ||||
| 1Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. | ||||
| 2Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| The present study investigates the antimicrobial effects of the total methanolic extracts and different fractions of Gelditsia triacanthos fruits and Gelditsia caspica leaves against G +ve and G –ve bacteria and fungi. Methanolic extract of G. caspica had prominent antifungal activity against A. niger about 88% of ketoconazole potency. Butanol extract of G. caspica had relative antimicrobial activity approximately 64% of Gentamicin standard against S. typhimurium. Butanol extract of G. triacanthos had moderate antifungal activity against A. niger approximately 73% of ketoconazole potency. Petroleum ether extract of G. triacanthos achieved antifungal activity approximately 75% of ketoconazole potency against C. Albicans whereas it had relative antimicrobial activity approximately 70% of Gentamicin standard against S. typhimurium. While anti-inflammatory properties of the total methanolic extracts and different fractions of Gelditsia triacanthos fruits and Gelditsia caspica leaves revealed that the ethyl acetate fraction of G. caspica has anti-inflammatory activity about 29% of the standard diclofenac, whereas, different fractions of G. caspica were found to be less effective as anti-inflammatory. Finally total methanolic extracts and different fractions of Gelditsia triacanthos fruits were evaluated for their anti-tuberculosis activity and showed that butanol extract of G. triacanthos achieved anti-mycobacterial potency about 0.006% of the standard isoniazid. | ||||
| Keywords | ||||
| Gelditsia triacanthos; Gelditsia caspica; antimicrobial; anti-inflammatory; anti-tuberculosis | ||||
|
Statistics Article View: 118 PDF Download: 79 |
||||
