Phytochemical and Biological Study of Melissa officinalis (Family Lamiaceae) Cultivated in Egypt
Seif El-Dein, N., AbdAlhady, N., Temraz, A., Abd-Elatiff, D., Ibrahim, M. (2023). Phytochemical and Biological Study of Melissa officinalis (Family Lamiaceae) Cultivated in Egypt. EKB Journal Management System, 3(1), 132-143. doi: 10.21608/aijpms.2022.138225.1145
Noha A Seif El-Dein; Nevein M AbdAlhady; Abeer SM Temraz; Doaa M Abd-Elatiff; Magda T Ibrahim. "Phytochemical and Biological Study of Melissa officinalis (Family Lamiaceae) Cultivated in Egypt". EKB Journal Management System, 3, 1, 2023, 132-143. doi: 10.21608/aijpms.2022.138225.1145
Seif El-Dein, N., AbdAlhady, N., Temraz, A., Abd-Elatiff, D., Ibrahim, M. (2023). 'Phytochemical and Biological Study of Melissa officinalis (Family Lamiaceae) Cultivated in Egypt', EKB Journal Management System, 3(1), pp. 132-143. doi: 10.21608/aijpms.2022.138225.1145
Seif El-Dein, N., AbdAlhady, N., Temraz, A., Abd-Elatiff, D., Ibrahim, M. Phytochemical and Biological Study of Melissa officinalis (Family Lamiaceae) Cultivated in Egypt. EKB Journal Management System, 2023; 3(1): 132-143. doi: 10.21608/aijpms.2022.138225.1145

Phytochemical and Biological Study of Melissa officinalis (Family Lamiaceae) Cultivated in Egypt

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 13, Volume 3, Issue 1, January 2023, Page 132-143  XML PDF (553.93 K)
Document Type: Original research articles
DOI: 10.21608/aijpms.2022.138225.1145
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Authors
Noha A Seif El-Dein email 1; Nevein M AbdAlhady1; Abeer SM Temrazorcid 1; Doaa M Abd-Elatiff2; Magda T Ibrahim1
1Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
2Department of Biochemistry, Faculty of Pharmacy, (Girls) Al-Azhar University, Cairo, 11651, Egypt.
Abstract
Phytochemical investigation of 70% aqueous methanol extract of leaves of lemon balm (Melissa officinalisL., Lamiaceae) was subjected to different chromatographic separation techniques. The structures of isolated compounds were determined on the basis of spectral data (UV, 1H-NMR, 13CNMR and mass spectrometry).Also, evaluation of the antioxidant, anticonvulsant, anti-inflammatory and antimicrobial activity were determined using different techniques.Result:three isoflavones;4'- methoxy genistein Biochanin A] (1),6, 8 dimethoxy- biochanin A -7 - O- α - L- rhamnopyranosyl (1'''-6'') - O -  - D- glucopyranoside (2), isoflavone 6, 8dimethoxy 7-O- - D rutinoside, 4'-O- α- L-rhamnopyranoside (3).Besides sixknown flavonoids; quercetin -3- O- β -D-galactopyranoside(hyperin)(4), luteolin 7-O- rhamnoside(5), scutellarein – 4',7 dimethyl ether(6), nepetin - 7- methyl ether(7),luteolin(8),and apigenin(9),in addition to caffeic acid(10), chlorogenic acid (11) isolated for the first time from Melissa officinalis. The investigated extract showed significant anticonvulsant activity, effective in inhibition of both acute & chronic inflammation. Scutellarein – 4',7-dimethyl ether sample(6) showed remarkable inhibition against fungi, and exhibited the highest antibacterial effect against both gram +ve and gram -ve bacteria. The above evidences suggest that Melissa officinalis leaves is a potential source of natural isoflavones and can be used to prevent convulsion, inflammation, can be used as antioxidant and antimicrobial drug.
Keywords
Melissa officinalis; isoflavones; antioxidant; anticonvulsant; anti-inflammatory; antimicrobial
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