Review Article: Is there a relationship between Systemic Lupus Erythematosus and the Mannose Binding Lectin gene?
sleem, S., Mahmoud kadry, Z., Gad, E., Abd Elall, A. (2023). Review Article: Is there a relationship between Systemic Lupus Erythematosus and the Mannose Binding Lectin gene?. EKB Journal Management System, 27(1), 13-21. doi: 10.21608/smj.2022.174446.1355
sara mostafa sleem; Zeinab Mahmoud kadry; Ebtisam Mohammed Gad; AlShimaa Hafez Abd Elall. "Review Article: Is there a relationship between Systemic Lupus Erythematosus and the Mannose Binding Lectin gene?". EKB Journal Management System, 27, 1, 2023, 13-21. doi: 10.21608/smj.2022.174446.1355
sleem, S., Mahmoud kadry, Z., Gad, E., Abd Elall, A. (2023). 'Review Article: Is there a relationship between Systemic Lupus Erythematosus and the Mannose Binding Lectin gene?', EKB Journal Management System, 27(1), pp. 13-21. doi: 10.21608/smj.2022.174446.1355
sleem, S., Mahmoud kadry, Z., Gad, E., Abd Elall, A. Review Article: Is there a relationship between Systemic Lupus Erythematosus and the Mannose Binding Lectin gene?. EKB Journal Management System, 2023; 27(1): 13-21. doi: 10.21608/smj.2022.174446.1355

Review Article: Is there a relationship between Systemic Lupus Erythematosus and the Mannose Binding Lectin gene?

Sohag Medical Journal
Volume 27, Issue 1, 2023, Page 13-21  XML PDF (725.23 K)
Document Type: Original Article
DOI: 10.21608/smj.2022.174446.1355
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Authors
sara mostafa sleem email 1; Zeinab Mahmoud kadry2; Ebtisam Mohammed Gad3; AlShimaa Hafez Abd Elall4
1Otorhinolarynglogy department, Sohag faculty of medicine, sohag university, sohag, Egypt.
2Department of Biochemistry, Faculty of Medicine Sohag University
3Department of chest disease and tuberculosis, Sohag faculty of medicine, Sohag University, Sohag, Egypt
4Medical Biochemistry Department, Faculty of medicine, Sohag University.
Abstract
Our review article discusses the relationship between systemic lupus erythematosus and the mannose-binding lectin gene. The complex trait of systemic lupus erythematosus (SLE), which manifests as a variety of clinical phenotypes and the production of several autoantibodies, is SLE. SLE patients experience a wide range of clinical phenotypes, such as skin rash, and neuropsychiatric, and musculoskeletal symptoms, some of which can progress to lupus nephritis. Abnormal complement activation causes inflammation, which damages multiple organs' tissue. About 50% of systemic lupus erythematosus patients, a chronic inflammatory disease, experience kidney damage. Despite effective anti-inflammatory and immunosuppressive therapies, lupus nephritis still results in end-stage kidney impairment (ESRD) or chronic kidney disorder (CKD) for an excessive number of patients. It represents a significant risk factor regarding mortality and morbidity in SLE. The family of C-type lectins of collectins includes the mannose-binding lectin (MBL), whose portion in the pre-immune first line of defense seems to involve pattern recognition. MBL can identify carbohydrate modes that abound on the surfaces of numerous pathogenic bacterial, viral, protozoal, and fungal microorganisms. The complement system's lectin pathway is activated when MBL binds to a microorganism. Numerous studies have linked MBL polymorphism, SLE, and lupus nephritis.
Keywords
Systemic lupus erythematosus (SLE); Lupus nephritis; Mannose-binding lectin (MBL)
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