Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats
Mahmoud, H., Kamel, E., Gad EL-Hak, H., Aldayel, T., Abdelrazek, H., Mohamed, Y., Noha, S., Abd Elghany, G. (2022). Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats. EKB Journal Management System, 89(2), 7719-7726. doi: 10.21608/ejhm.2022.277126
Hany Salah Mahmoud; Eman Mohamed Kamel; Heba Nageh Gad EL-Hak; Tahany Saleh Aldayel; Heba M.A. Abdelrazek; Yousra Reda Arafa Mohamed; Shebl Noha; Ghada Mohamed Abd Elghany. "Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats". EKB Journal Management System, 89, 2, 2022, 7719-7726. doi: 10.21608/ejhm.2022.277126
Mahmoud, H., Kamel, E., Gad EL-Hak, H., Aldayel, T., Abdelrazek, H., Mohamed, Y., Noha, S., Abd Elghany, G. (2022). 'Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats', EKB Journal Management System, 89(2), pp. 7719-7726. doi: 10.21608/ejhm.2022.277126
Mahmoud, H., Kamel, E., Gad EL-Hak, H., Aldayel, T., Abdelrazek, H., Mohamed, Y., Noha, S., Abd Elghany, G. Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats. EKB Journal Management System, 2022; 89(2): 7719-7726. doi: 10.21608/ejhm.2022.277126

Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats

The Egyptian Journal of Hospital Medicine
Article 242, Volume 89, Issue 2, October 2022, Page 7719-7726  XML PDF (1.08 MB)
DOI: 10.21608/ejhm.2022.277126
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Authors
Hany Salah Mahmoud1; Eman Mohamed Kamel2; Heba Nageh Gad EL-Hak3; Tahany Saleh Aldayel* 4; Heba M.A. Abdelrazek5; Yousra Reda Arafa Mohamed6; Shebl Noha7; Ghada Mohamed Abd Elghany3
11Center of Scientific Foundation for Experimental Studies and Research, Ismailia, Egypt
2Department of 2Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Egypt
3Department of 3Zoology, Faculty of Sciences, Suez Canal University, Egypt
4Department of 4Health Sciences, Clinical Nutrition, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
5Departments of 5Physiology,
66Forensic Medicine & Toxicology
77Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a flavor enhancer. It is now utilized in many processed foods and by most fast-food chains. Honey is a potent antioxidant that acts in the body against many diseases.
Objective: The aim of the current study is to investigate honey's ameliorative effect on kidney damage initiated by monosodium glutamate in adult male rats. Moreover, different polyphenolic compounds in the crude honey were evaluated.
Material and methods: Forty adult male albino rats were equally divided into four groups (N=6): The Control group was administered 1 mL of saline daily orally, the MSG group (30 g/kg on diet), the Honey group (2.5 g/kg body weight/day, orally) and Honey/MSG group as the previous for one month.
Results: Urea, creatinine, and uric acid were significantly increased in the MSG group and decreased in the honey/MSG group compared to the control group. MSG markedly destructed glomeruli of the kidney and increased the immunoexpressing of nuclear erythroid-related factor 2 (Nrf2) and tumor necrosis factor-alpha (TNF-a).
Conclusions: Administration of crude honey attenuates and improves the kidney pathological changes induced by MSG.
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