Ethno-pharmacological activity of the medicinal plant Chrysanthemum‘dante purple’ | ||||
| Azhar International Journal of Pharmaceutical and Medical Sciences | ||||
| Article 8, Volume 3, Issue 1, January 2023, Page 86-95 PDF (330.16 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/aijpms.2022.136461.1142 | ||||
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| Authors | ||||
Shaimaa Negm El-Dein   1; Amal H Ahmed 1; Marwa S Abu Bakr 1; Asmaa Negm El-Dein 2; Hanem M Awad 3; Ehab A Ragab 4
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| 1Department of Pharmacognosy, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt | ||||
| 2Department of Chemistry of Natural and Microbial Products, National Research Center, Dokki, Giza, Egypt | ||||
| 3Department of Tanning Materials and Leather Technology, National Research Center, Dokki, Giza, Egypt | ||||
| 4Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Six compounds were extracted from the ethyl acetate fraction of Chrysanthemum dante purple flowers for the first time, and identified as ;luteolin (1), quercetin (2), apigenin 7-O-β-D-glucopyranoside (3), luteolin 7-O-β-D-glucopyranoside (4), rutin (5) and daucosterol (6). The structures of the extracted compounds had been established by comparison of their NMR and MS data with published ones. Free radical scavenging activity of flowers compound (1), total methanolic extract and fractions and confirmed that they had potent antioxidant activity even with lower concentrations, IC50 of all tested samples was temperately low between 0.3 and 0.6 mg/ml. All samples showed also potent cholesterol reduction ability. Concerning anti-inflammatory activity, the protection provided by compound (1), (luteolin), and butanol fraction were the most potent even with the lowest concentration. Further anti-proliferative activity of all tested samples showed good anti-tumor activity even with low concentrations against human colorectal (HCT-116) and hepatic (HepG-2) cancer cells exceeding Doxorubicin and moderate antitumor activity against breast (MCF-7) cancer with no cytotoxic activity against BJ-1 human skin healthy cell-line.This could promote the use of C. dante purple flower extract for pharmacological and health purposes. | ||||
| Keywords | ||||
| Chrysanthemum dante purple; phytoconstituents; antioxidant; anti-cholesterol; anti-inflammatory; anti-proliferative activities | ||||
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