Biochemical Study of The Ameliorative Influences of Fennel Oil against Cyproconazole-Induced Adrenal Gland Damage in Albino Rats
Yousef, H., Ramadan, R., Sakr, I., Aboelwafa, H. (2022). Biochemical Study of The Ameliorative Influences of Fennel Oil against Cyproconazole-Induced Adrenal Gland Damage in Albino Rats. EKB Journal Management System, 89(2), 7964-7974. doi: 10.21608/ejhm.2022.277479
Hany N Yousef; Ramadan A. Ramadan; Inas H. Sakr; Hanaa R. Aboelwafa. "Biochemical Study of The Ameliorative Influences of Fennel Oil against Cyproconazole-Induced Adrenal Gland Damage in Albino Rats". EKB Journal Management System, 89, 2, 2022, 7964-7974. doi: 10.21608/ejhm.2022.277479
Yousef, H., Ramadan, R., Sakr, I., Aboelwafa, H. (2022). 'Biochemical Study of The Ameliorative Influences of Fennel Oil against Cyproconazole-Induced Adrenal Gland Damage in Albino Rats', EKB Journal Management System, 89(2), pp. 7964-7974. doi: 10.21608/ejhm.2022.277479
Yousef, H., Ramadan, R., Sakr, I., Aboelwafa, H. Biochemical Study of The Ameliorative Influences of Fennel Oil against Cyproconazole-Induced Adrenal Gland Damage in Albino Rats. EKB Journal Management System, 2022; 89(2): 7964-7974. doi: 10.21608/ejhm.2022.277479

Biochemical Study of The Ameliorative Influences of Fennel Oil against Cyproconazole-Induced Adrenal Gland Damage in Albino Rats

The Egyptian Journal of Hospital Medicine
Article 279, Volume 89, Issue 2, October 2022, Page 7964-7974  XML PDF (835.23 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.277479
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Authors
Hany N Yousef email orcid 1; Ramadan A. Ramadan2; Inas H. Sakr2; Hanaa R. Aboelwafa2
1Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, Cairo, Egypt
2Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, Cairo 11566, Egypt
Abstract
Background: Cyproconazole (CPZ) is a triazole fungicide used to protect crops against a variety of fungal diseases.
Objective: This investigation aimed to evaluate the probable protective benefits of fennel oil, a natural oil extracted from the plant Foeniculum Vulgare, against CPZ-induced adrenal gland injury in rats.
Methods: Sixty male rats were allocated into: control, fennel oil, CPZ-low dose, CPZ-high dose, CPZ-low dose + fennel oil, and CPZ-high dose + fennel oil. After 15 days of daily treatment, serum levels of adrenocorticotropic hormone (ACTH), cortisol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), and free cholesterol (FC) were estimated. The adrenal gland tissues were also investigated to assess the amount of reduced glutathione (GSH), malondialdehyde (MDA), the efficacy of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), along with evaluating the status of DNA fragmentation using the Comet assay.
Results: CPZ substantially induced damage in the adrenal gland, as evidenced by elevated serum levels of ACTH, TC, FC, and LDL-c as well as reduced serum levels of cortisol and HDL-c. Also, high levels of MDA, decreased GSH levels, and diminished activities of SOD, CAT, and GPx in adrenal gland tissues in CPZ-treated groups. Furthermore, CPZ caused DNA damage in adrenal gland cells. Fennel oil co-treatment reversed CPZ hazardous effects on the biochemical parameters and DNA damage. Conclusion: This study claimed that fennel oil co-treatment could ameliorate CPZ-induced adrenal gland injury in male rats.
Keywords
Triazole; Fungicide; Cyproconazole; Fennel oil; Adrenal gland; Biochemistry
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