Methylenetetrahydrofolate Reductase and Peroxisome Proliferator-Activated Receptor-γ Gene Polymorphisms and Risk of Obesity in Females of Madina, Saudi Arabia | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Volume 43, Issue 1, January 2023, Page 64-74 PDF (660.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2022.171402.1130 | ||||
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| Authors | ||||
Moutasem S. Aboonq1; Magda H.M. Youssef1; Sherif A. El-Kafrawy2; Tamer Hifnawy3; Moaz Mojaddidi1; Eman A-Fadhly4; Shereen Eltarhony5; Ahmed Abdulhakim ElGendy 6; Elsayed A. Eid  7
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| 1Department of Medical Physiology, Faculty of Medicine, Taibah University, Al-Madina Al Monawarah, Saudi Arabia. | ||||
| 2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. | ||||
| 3Medical Education Department, College of Dentistry, Taibah University, Al Madinah Al Monawarah, Saudi Arabia. | ||||
| 4Department of Medicine, College of Medicine, Taibah University, Al Madinah Al Monawarah, Saudi Arabia. | ||||
| 5Medical biochemistry department, Faculty of Medicine, Zagazig university | ||||
| 6Department of Medical Physiology,Faculty of Medicine,Mansoura University,Mansoura ,Egypt. | ||||
| 7Department of endocrinology and internal Medicine Department, Delta University, Gamasa, Egypt | ||||
| Abstract | ||||
| Aim: The aim of this study is to evaluate the association of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and peroxisome proliferator-activated receptor (PPAR) genes with obesity among adult females in Al-Madina, Saudi Arabia. Method: The participants in this study were 114 healthy females aged 18–60 years. Body mass index (BMI) and body composition parameters were assessed. Triglycerides, total cholesterol, HDL, and LDL were measured. Real-time PCR was used to detect the selected genetic polymorphisms of PPAR-γ rs1801282 and MTHFR rs1801131. Results: Weight, BMI, fat-percentage, FFM, truncal fat mass, and LDL were significantly higher in the overweight and obese group than in the normal BMI group. PPAR-γ genotype and allele polymorphism frequencies in the overweight and obesity group showed no statistically significant differences compared to those of the normal weight group. However, a significant difference was found between the frequency of both T and G alleles of MTHFR in the normal BMI and overweight and obese group (p = 0.03) and a significant correlation with the fat-percentage in both groups (p = 0.01). A significant correlation between the MTHFR genotypes and the fat-percentage in both groups was also found (p = 0.04). Conclusion: In this population of Saudi females, we found that MTHFR GG genotype and G allele are significantly correlated with the deposition of fat in the body; women with this allele and genotype should be advised to control their weight and fat intake, as this is also associated with LDL levels that may affect their cardiovascular system. | ||||
| Keywords | ||||
| obesity; polymorphism; PPAR-γ; MTHFR | ||||
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