Hospital-Acquired Infection by Carbapenem-Resistant Acinetobacter Species in ICUs in Assiut, Egypt
Ibrahim, M., Abdallah, S., Soliman, I., Afifi, N., Atiat Allah, M. (2023). Hospital-Acquired Infection by Carbapenem-Resistant Acinetobacter Species in ICUs in Assiut, Egypt. EKB Journal Management System, 32(1), 97-104. doi: 10.21608/ejmm.2023.277785
Maggie Abdallah Ibrahim; Shereen Abdallah; Ismail Seddik Soliman; Noha Afifi; Michael Nazmy Agban Atiat Allah. "Hospital-Acquired Infection by Carbapenem-Resistant Acinetobacter Species in ICUs in Assiut, Egypt". EKB Journal Management System, 32, 1, 2023, 97-104. doi: 10.21608/ejmm.2023.277785
Ibrahim, M., Abdallah, S., Soliman, I., Afifi, N., Atiat Allah, M. (2023). 'Hospital-Acquired Infection by Carbapenem-Resistant Acinetobacter Species in ICUs in Assiut, Egypt', EKB Journal Management System, 32(1), pp. 97-104. doi: 10.21608/ejmm.2023.277785
Ibrahim, M., Abdallah, S., Soliman, I., Afifi, N., Atiat Allah, M. Hospital-Acquired Infection by Carbapenem-Resistant Acinetobacter Species in ICUs in Assiut, Egypt. EKB Journal Management System, 2023; 32(1): 97-104. doi: 10.21608/ejmm.2023.277785

Hospital-Acquired Infection by Carbapenem-Resistant Acinetobacter Species in ICUs in Assiut, Egypt

Egyptian Journal of Medical Microbiology
Volume 32, Issue 1, January 2023, Page 97-104  XML PDF (440.92 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2023.277785
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Authors
Maggie Abdallah Ibrahim email 1; Shereen Abdallah2; Ismail Seddik Soliman3; Noha Afifi1; Michael Nazmy Agban Atiat Allah4
1Microbiology and Immunology Department, Faculty of Medicine, Assiut University
2Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University
3Microbiology and Immunology department, Assiut university
4Medical Microbiology and Immunology , Faculty of Medicine, Assiut University,
Abstract
Background: The genus Acinetobacter is one of the main fears of hospital-acquired infection (HAI) wide-reaching mostly in ICUs. Objectives: This study aimed to identify the incidence of carbapenem-resistant Acinetobacter (CRA) HAI in Assiut University Hospitals ICU and determine their antimicrobial susceptibility profile. Methodology: The study included 1204 clinical samples from 928 patients with HAI and 625 environmental samples. Carbapenemase production was detected phenotypically by MIC determination using imipenem, meropenem and doripenem E-test, modified Hodge test, combined disc test and double disc synergy test (DDST). OXA genes (blaOXA-51, blaOXA-23, blaOXA-24, and blaOXA-58) and MβL genes (blaSIM-1, blaVIM, and blaIMP-1) were investigated genotypically by PCR. Results: Out of total 60 Acinetobacter isolates, 55 (91.7%) were extensively drug-resistant (XDR) and 5 (8.3%) were multi-drug resistant (MDR). 93.3% of Acinetobacter isolates were resistant to imipenem and meropenem, and 90% were resistant to doripenem. The prevalence of bla genes in isolates were blaOXA-51 (93.3%), blaOXA-23 (68.3%), blaOXA-24 (23.3%), blaOXA-58 (10%), blaSIM-1 (46.7%), and blaVIM (8.3%). blaIMP-1 was not detected in any isolate. Conclusion: CRA infections were considerable in our ICUs. The high prevalence of XDR Acinetobacter spp. observed in our study was very alarming and requires critical intervention.
Keywords
Hospital-acquired infection; carbapenem-resistance; extensive drug-resistance; Acinetobacter
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